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Tchem
ACPP
Prostatic acid phosphatase

Protein Summary
Description
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336375
  • ENSP00000337471
  • ENSG00000014257
  • ENST00000351273
  • ENSP00000323036
  • ENST00000475741
  • ENSP00000417744

Symbol
  • ACP3
  • 5'-NT
  • ACP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.97
virus perturbation
0.9
disease perturbation
0.87
molecular function
0.81
gene perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.89   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 837   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.89   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 837   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (6)
1 – 6 of 6
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
51.4
smoking status measurement
2
1
2
50.6
total cholesterol measurement
1
2
2
41.8
low density lipoprotein cholesterol measurement
1
1
1
33.1
apolipoprotein B measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
51.4
smoking status measurement
2
50.6
total cholesterol measurement
2
41.8
low density lipoprotein cholesterol measurement
1
33.1
apolipoprotein B measurement
1
30.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase, prostate
VGNC:8778
460702
Macaque
acid phosphatase, prostate
717786
Mouse
MGI:1928480
56318
Rat
RGD:2023
56780
Dog
acid phosphatase, prostate
485662
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase, prostate
Macaque
acid phosphatase, prostate
Mouse
Rat
Dog
acid phosphatase, prostate
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15309-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (116)
1 – 10 of 116
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.999767832
p_ni:  0.000232162
p_wrong:  6e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.99958585
p_ni:  0.00041415
p_wrong:  1e-9
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999357742
p_ni:  0.000642031
p_wrong:  2.26e-7
Data Source:  BioPlex
MMRN1
Tbio
Novelty:  0.03378128
p_int:  0.999138049
p_ni:  0.000861936
p_wrong:  1.5e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.998991045
p_ni:  0.001008928
p_wrong:  2.7e-8
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.996497462
p_ni:  0.003502523
p_wrong:  1.5e-8
Data Source:  BioPlex
CCDC103
Tbio
Novelty:  0.07857649
p_int:  0.99586149
p_ni:  0.004138469
p_wrong:  4.1e-8
Data Source:  BioPlex
CPLX3
Tbio
Novelty:  0.07332857
p_int:  0.993543056
p_ni:  0.006102908
p_wrong:  0.000354036
Data Source:  BioPlex
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.991133848
p_ni:  0.008866152
Data Source:  BioPlex
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
p_int:  0.986807517
p_ni:  0.013192482
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  289.89

PubMed score by year
PubTator Score  951.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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