Tchem ACPP Prostatic acid phosphatase

Protein Summary

Description

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• P15309
• D3DNC6
• Q5FBY0
• Q96KY0
• Q96QK9
• Q96QM0
• PAP

Gene Name

• ACPP

Ensembl ID

• ENST00000336375
• ENSP00000337471
• ENSG00000014257
• ENST00000351273
• ENSP00000323036
• ENST00000475741
• ENSP00000417744

Symbol

• ACP3
• 5'-NT
• ACP-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.97
virus perturbation	0.9
disease perturbation	0.87
molecular function	0.81
gene perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Prostatic Acid Phosphatase

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Prostatic Acid Phosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.72   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 837   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.72   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 837   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0