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Tbio
B4GALT1
Beta-1,4-galactosyltransferase 1

Protein Summary
Description
The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-ter ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379731
  • ENSP00000369055
  • ENSG00000086062

Symbol
  • GGTB2
  • GT1
  • GTB
  • CDG2D
  • GGTB2
  • B4GAL-T1
  • beta4Gal-T1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
biological process
0.95
PubMedID
0.91
transcription factor binding site profile
0.91
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.96   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.96   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
2
2
2
95.6
urate measurement
2
2
2
85.8
hemoglobin measurement
2
2
2
60.6
mathematical ability
1
1
1
54.7
red blood cell density measurement
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
2
95.6
urate measurement
2
85.8
hemoglobin measurement
2
60.6
mathematical ability
1
54.7
red blood cell density measurement
1
43.5
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (39)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Disease
Diseases associated with N-glycosylation of proteins
Diseases associated with glycosaminoglycan metabolism
Gene Ontology Terms (45)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (174)
1 – 10 of 174
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.991684651
p_ni: 0.008315349
Data Source: BioPlex
TMPRSS11B
Tdark
Family: Enzyme
Novelty: 1.20690443
p_int: 0.969303441
p_ni: 0.030689888
p_wrong: 0.000006671
Data Source: BioPlex
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
p_int: 0.94019878
p_ni: 0.05980122
Data Source: BioPlex
MMP10
Tchem
Novelty: 0.00112113
p_int: 0.938743138
p_ni: 0.061256689
p_wrong: 1.73e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.938141515
p_ni: 0.061858485
Data Source: BioPlex
SLC7A14
Tbio
Family: Transporter
Novelty: 0.1613451
p_int: 0.932373712
p_ni: 0.06761114
p_wrong: 0.000015148
Data Source: BioPlex
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.868555253
p_ni: 0.131443545
p_wrong: 0.000001203
Data Source: BioPlex
IL27RA
Tbio
Novelty: 0.01348051
p_int: 0.85701266
p_ni: 0.142987037
p_wrong: 3.02e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
TNF
Tclin
Novelty: 0.00001457
p_int: 0.838687048
p_ni: 0.161312842
p_wrong: 1.1e-7
Score: 0.17
Data Source: BioPlex,STRINGDB
FAM234B
Tdark
Novelty: 1.53957047
p_int: 0.816722555
p_ni: 0.183275028
p_wrong: 0.000002417
Data Source: BioPlex
Publication Statistics
PubMed Score  137.96

PubMed score by year
PubTator Score  239.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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