Tbio ARSA Arylsulfatase A

Protein Summary

Description

Hydrolyzes cerebroside sulfate. The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• P15289
• B2RCA6
• B7XD04
• F8WCC8
• Q6ICI5
• Q96CJ0
• ASA

Gene Name

• ARSA

Ensembl ID

• ENST00000453344
• ENSP00000412542
• ENSG00000100299

Symbol

• ASA
• MLD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
cellular component	0.8
virus perturbation	0.68
PubMedID	0.66
transcription factor binding site profile	0.64

Protein Classes

PANTHER Classes

Protein / Hydrolase / Arylsulfatase A

DTO Classes

Protein / Enzyme / Hydrolase / Arylsulfatase A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.43   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 413   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.43   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0