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Tbio
IFNGR1
Interferon gamma receptor 1

Protein Summary
Description
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550). This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367739
  • ENSP00000356713
  • ENSG00000027697

Symbol
  • CD119
  • IFNGR
  • IMD27A
  • IMD27B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.82
transcription factor perturbation
0.8
phenotype
0.78
hub protein
0.71
PubMedID
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.07   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 700   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.07   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 700   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.1
97.5
body mass index
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
97.5
body mass index
1
1.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon gamma receptor 1
VGNC:3122
747276
Mouse
MGI:107655
15979
Rat
RGD:620570
116465
Dog
interferon gamma receptor 1
VGNC:41880
100856077
Horse
interferon gamma receptor 1
VGNC:18952
100073195
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon gamma receptor 1
Mouse
Rat
Dog
interferon gamma receptor 1
Horse
interferon gamma receptor 1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (86)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Reactome
Regulation of IFNG signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Regulation of IFNG signaling
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (154)
1 – 10 of 154
MAD2L2
Tbio
Novelty: 0.01091072
p_int: 0.999442161
p_ni: 0.000557839
Data Source: BioPlex
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
p_int: 0.969148556
p_ni: 0.030796204
p_wrong: 0.00005524
Score: 0.342
Data Source: BioPlex,STRINGDB
NDFIP1
Tbio
Novelty: 0.04496467
p_int: 0.963144824
p_ni: 0.036855176
Score: 0.518
Data Source: BioPlex,STRINGDB
CD320
Tbio
Novelty: 0.01978884
p_int: 0.947081282
p_ni: 0.052867445
p_wrong: 0.000051273
Data Source: BioPlex
RHOU
Tbio
Family: Enzyme
Novelty: 0.01456329
p_int: 0.945747576
p_ni: 0.000009858
p_wrong: 0.054242566
Score: 0.195
Data Source: BioPlex,STRINGDB
IFNG
Tclin
Novelty: 0.00009731
p_int: 0.944341014
p_ni: 0.055658986
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
RAET1E
Tbio
Novelty: 0.01859274
p_int: 0.934968759
p_ni: 0.065031241
Score: 0.172
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.927898739
p_ni: 0.07164351
p_wrong: 0.000457751
Score: 0.296
Data Source: BioPlex,STRINGDB
SLC9A6
Tbio
Family: Transporter
Novelty: 0.01410234
p_int: 0.904758279
p_ni: 0.094851757
p_wrong: 0.000389964
Score: 0.556
Data Source: BioPlex,STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
p_int: 0.895969885
p_ni: 0.102607385
p_wrong: 0.00142273
Score: 0.638
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  246.07

PubMed score by year
PubTator Score  162.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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