MYOD1
Myoblast determination protein 1
Protein Summary
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
- ENST00000250003
- ENSP00000250003
- ENSG00000129152
- BHLHC1
- MYF3
- MYOD
- PUM
- MYF3
- MYOD
- bHLHc1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
hub protein | 0.99 | ||
molecular function | 0.99 | ||
gene perturbation | 0.98 | ||
kinase | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1996.45 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 976 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1996.45 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 976 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 42
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0