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Tbio
GSPT1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Protein Classes
Protein Summary
Description
Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420576
  • ENSP00000399539
  • ENSG00000103342
  • ENST00000434724
  • ENSP00000398131
  • ENST00000439887
  • ENSP00000408399
  • ENST00000563468
  • ENSP00000454351

Symbol
  • ERF3A
  • GST1
  • ETF3A
  • eRF3a
  • 551G9.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.97
disease perturbation
0.96
transcription factor binding site profile
0.94
transcription factor perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.02   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.02   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
4
80
reticulocyte count
1
1
1
61.4
testosterone measurement
2
2
2
60.8
sex hormone-binding globulin measurement
2
1
2
49.5
red blood cell density measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
4
80
reticulocyte count
1
61.4
testosterone measurement
2
60.8
sex hormone-binding globulin measurement
2
49.5
red blood cell density measurement
1
47.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G1 to S phase transition 1
454075
Macaque
G1 to S phase transition 1
716860
Dog
G1 to S phase transition 1
VGNC:41533
479846
Horse
G1 to S phase transition 1
VGNC:18622
100055960
Anole lizard
eukaryotic peptide chain release factor GTP-binding subunit ERF3A
100565460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G1 to S phase transition 1
Macaque
G1 to S phase transition 1
Dog
G1 to S phase transition 1
Horse
G1 to S phase transition 1
Anole lizard
eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15170-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Eukaryotic Translation Termination
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Eukaryotic Translation Termination
Metabolism of RNA
Metabolism of proteins
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (276)
1 – 10 of 276
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.999999993
p_ni:  7e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.993456205
p_ni:  0.006543795
Score:  0.179
Data Source:  BioPlex,STRINGDB
VBP1
Tbio
Novelty:  0.0428293
p_int:  0.810343868
p_ni:  0.189656132
Score:  0.271
Data Source:  BioPlex,STRINGDB
SMG1
Tchem
Family:  Kinase
Novelty:  0.00854339
Score:  0.999
Data Source:  STRINGDB
UPF1
Tbio
Novelty:  0.00311006
Score:  0.999
Data Source:  STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
Score:  0.999
Data Source:  Reactome,STRINGDB
PABPC1
Tbio
Novelty:  0.00197523
Score:  0.999
Data Source:  STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.997
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.997
Data Source:  STRINGDB
RPS14
Tbio
Novelty:  0.00576737
Score:  0.996
Data Source:  STRINGDB
Publication Statistics
PubMed Score  40.02

PubMed score by year
PubTator Score  22.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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