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Tbio
RAC2
Ras-related C3 botulinum toxin substrate 2

Protein Summary
Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249071
  • ENSP00000249071
  • ENSG00000128340

Symbol
  • Gx
  • EN-7
  • HSPC022
  • p21-Rac2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.93
hub protein
0.9
molecular function
0.9
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 658.34   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 658.34   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
3
3
90.8
eosinophil count
1
2
2
87.5
2
1
0
1.4
79.9
autoimmune thyroid disease
1
1
0
1.1
79.8
Thyroid preparation use measurement
1
1
1
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
3
90.8
eosinophil count
2
87.5
0
1.4
79.9
autoimmune thyroid disease
0
1.1
79.8
Thyroid preparation use measurement
1
78.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97846
19354
Rat
RGD:1307568
366957
Dog
Rac family small GTPase 2
VGNC:49610
481271
Horse
Rac family small GTPase 2
VGNC:49130
100054701
Cow
Rac family small GTPase 2
VGNC:49061
327671
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Rac family small GTPase 2
Horse
Rac family small GTPase 2
Cow
Rac family small GTPase 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15153-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (79)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
GPVI-mediated activation cascade
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Disease
Diseases of signal transduction
GPVI-mediated activation cascade
Protein-Protein Interactions (504)
1 – 10 of 504
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
p_int:  0.999999905
p_wrong:  9.4e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
DOCK1
Tbio
Novelty:  0.00867391
p_int:  0.999891979
p_ni:  0.000108019
p_wrong:  2e-9
Score:  0.959
Data Source:  BioPlex,STRINGDB
ELMO2
Tbio
Novelty:  0.04258272
p_int:  0.99919353
p_ni:  0.00080647
Score:  0.705
Data Source:  BioPlex,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.772465624
p_ni:  0.227534376
Score:  0.779
Data Source:  BioPlex,STRINGDB
ARHGDIB
Tbio
Novelty:  0.01139758
Score:  0.998
Data Source:  STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.994
Data Source:  Reactome,STRINGDB
DOCK2
Tchem
Novelty:  0.01570974
Score:  0.993
Data Source:  STRINGDB
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.992
Data Source:  STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.989
Data Source:  Reactome,STRINGDB
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.987
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  658.34

PubMed score by year
PubTator Score  232.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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