Tbio RAC2 Ras-related C3 botulinum toxin substrate 2

Protein Summary

Description

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P15153
• Q9UDJ4

Gene Name

• RAC2

Ensembl ID

• ENST00000249071
• ENSP00000249071
• ENSG00000128340

Symbol

• Gx
• EN-7
• HSPC022
• p21-Rac2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
kinase perturbation	0.93
hub protein	0.9
molecular function	0.9
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Ras-related C3 Botulinum Toxin Substrate 2

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Ras-related C3 Botulinum Toxin Substrate 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.9   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.9   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0