Tchem ANPEP Aminopeptidase N

Protein Summary

Description

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15144
• Q16728
• Q6GT90
• Q8IUK3
• Q8IVH3
• Q9UCE0
• AP-N

Gene Name

• ANPEP

Ensembl ID

• ENST00000300060
• ENSP00000300060
• ENSG00000166825

Symbol

• APN
• CD13
• PEPN
• APN
• CD13
• LAP1
• P150
• PEPN
• GP150

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
biological term	0.8
kinase perturbation	0.76
disease	0.75
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Aminopeptidase N

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Aminopeptidase N

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2525.48   (req: < 5)

Gene RIFs: 113   (req: <= 3)

Antibodies: 1730   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2525.48   (req: >= 5)

Gene RIFs: 113   (req: > 3)

Antibodies: 1730   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 163

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1