Tclin AKR1B1 Aldose reductase

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Aldose Reductase

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Aldose Reductase

Protein Summary

Description

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• P15121
• B2R8N3
• Q5U031
• Q6FGA4
• Q6ICP2
• Q9BS21
• Q9UCI9
• AR

Gene Name

• AKR1B1

Ensembl ID

• ENST00000285930
• ENSP00000285930
• ENSG00000085662

Symbol

• ALDR1
• AR
• ADR
• ALR2
• ALDR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.98
transcription factor perturbation	0.97
drug	0.96
chemical	0.95

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2250.92   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 465   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2250.92   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 490

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5

Approved Drugs (5)

Explore Approved Drugs

1 – 5 of 5

quercetin

AKR1B1Tclin Enzyme

IC50 : 7.83

sulindac

AKR1B1Tclin Enzyme

IC50 : 6.43

gossypol

AKR1B1Tclin Enzyme

Ki : 6.3

tolrestat

AKR1B1Tclin Enzyme

INHIBITOR IC50 : 8.5086

epalrestat

AKR1B1Tclin Enzyme

INHIBITOR IC50 : 7.6778

Active Ligands (490)

Explore Active Ligands

1 – 10 of 490

Luteolin

AKR1B1Tclin Enzyme

IC50 : 6.22

Ellagic acid

AKR1B1Tclin Enzyme

IC50 : 6.7

Caffeic acid Phenethyl Ester

AKR1B1Tclin Enzyme

IC50 : 6.24

CHEMBL4081954

AKR1B1Tclin Enzyme

IC50 : 6.69

CHEMBL4089817

AKR1B1Tclin Enzyme

IC50 : 6.56

zopolrestat

AKR1B1Tclin Enzyme

Ki : 7.72

p-Coumaric Acid

AKR1B1Tclin Enzyme

IC50 : 6.85

Minalrestat

AKR1B1Tclin Enzyme

IC50 : 7.91

Gossylic lactone

AKR1B1Tclin Enzyme

Ki : 6.82

AZD1981

AKR1B1Tclin Enzyme

IC50 : 6.1

GWAS Traits (4)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diastolic blood pressure	EFO_0006336	1	1	1		61.4
Agents acting on the renin-angiotensin system use measurement	EFO_0009931	1	1	1		39.6
response to diuretic	GO_0036270	1	1	0	19.1	0
systolic blood pressure change measurement	EFO_0006944	1	1	0	19.1	0

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diastolic blood pressure	EFO_0006336	1		61.4
Agents acting on the renin-angiotensin system use measurement	EFO_0009931	1		39.6
response to diuretic	GO_0036270	0	19.1	0
systolic blood pressure change measurement	EFO_0006944	0	19.1	0

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	aldo-keto reductase family 1 member B	VGNC:13628	737737
Mouse	aldo-keto reductase family 1, member B3 (aldose reductase)	MGI:1353494	11677
Rat	aldo-keto reductase family 1 member B	RGD:2092	24192
Horse	aldo-keto reductase family 1 member B	VGNC:15214	100065145
Cow	aldo-keto reductase family 1, member B1 (aldose reductase)		317748

Species	Name	OMA	EggNOG	Inparanoid
Chimp	aldo-keto reductase family 1 member B
Mouse	aldo-keto reductase family 1, member B3 (aldose reductase)
Rat	aldo-keto reductase family 1 member B
Horse	aldo-keto reductase family 1 member B
Cow	aldo-keto reductase family 1, member B1 (aldose reductase)

Protein Structure (140 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15121-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 140

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (19)

Reactome (8)

KEGG (6)

PathwayCommons (2)

WikiPathways (3)

Fructose biosynthesis (R-HSA-5652227)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Fructose biosynthesis	2 targets	R-HSA-5652227
Reactome	Fructose metabolism	7 targets	R-HSA-5652084
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of carbohydrates	293 targets	R-HSA-71387
Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Name	Explore in Pharos	Explore in Source
Fructose biosynthesis	2 targets	R-HSA-5652227
Fructose metabolism	7 targets	R-HSA-5652084
Metabolism	2112 targets	R-HSA-1430728
Metabolism of carbohydrates	293 targets	R-HSA-71387
Metabolism of lipids	740 targets	R-HSA-556833

Gene Ontology Terms (38)

Functions (5)

Components (10)

Processes (23)

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1 – 5 of 5

GO Term	Evidence	Assigned by
alditol:NADP+ 1-oxidoreductase activity	Inferred from Direct Assay (IDA)	UniProtKB
glyceraldehyde oxidoreductase activity	Inferred from Direct Assay (IDA)	UniProtKB
alcohol dehydrogenase (NADP+) activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oxidoreductase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
electron transfer activity	Traceable Author Statement (TAS)	UniProtKB

Protein-Protein Interactions (171)

Explore Interacting Targets

1 – 10 of 171

• See Interactions on String-DB

AKR1B15

Tbio

Family:  Enzyme

Novelty:  0.29076067

p_int:  0.999929771

p_ni:  0.000070229

Score:  0.701

Data Source:  BioPlex,STRINGDB

SORD

Tchem

Family:  Enzyme

Novelty:  0.0040485

Score:  0.996

Data Source:  STRINGDB

DHDH

Tbio

Family:  Enzyme

Novelty:  0.00284827

Score:  0.96

Data Source:  STRINGDB

SPR

Tchem

Family:  Enzyme

Novelty:  0.02144934

Score:  0.957

Data Source:  STRINGDB

DHFR

Tclin

Family:  Enzyme

Novelty:  0.00074557

Score:  0.951

Data Source:  STRINGDB

DCXR

Tbio

Family:  Enzyme

Novelty:  0.00967328

Score:  0.94

Data Source:  STRINGDB

GK

Tbio

Family:  Kinase

Novelty:  0.00617547

Score:  0.929

Data Source:  STRINGDB

QDPR

Tchem

Family:  Enzyme

Novelty:  0.00836889

Score:  0.929

Data Source:  STRINGDB

GALM

Tbio

Family:  Enzyme

Novelty:  0.01067063

Score:  0.928

Data Source:  STRINGDB

TPH1

Tclin

Family:  Enzyme

Novelty:  0.00098637

Score:  0.926

Data Source:  STRINGDB

Publication Statistics

PubMed Score  2250.92

PubMed score by year

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PubTator Score  1494.53

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
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Cytoplasm
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NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

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Agents acting on the renin-angiotensin system use measurement
diastolic blood pressure
response to diuretic
systolic blood pressure change measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
renal/urinary system phenotype