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Tclin
AKR1B1
Aldose reductase

Protein Summary
Description
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285930
  • ENSP00000285930
  • ENSG00000085662

Symbol
  • ALDR1
  • AR
  • ADR
  • ALR2
  • ALDR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.98
transcription factor perturbation
0.97
drug
0.96
chemical
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2250.92   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 465   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2250.92   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 490
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Active Ligands (490)
1 – 10 of 490
Luteolin
Rendered image for Luteolin
Ellagic acid
Rendered image for Ellagic acid
Caffeic acid Phenethyl Ester
Rendered image for Caffeic acid Phenethyl Ester
CHEMBL4081954
Rendered image for CHEMBL4081954
CHEMBL4089817
Rendered image for CHEMBL4089817
zopolrestat
Rendered image for zopolrestat
p-Coumaric Acid
Rendered image for p-Coumaric Acid
Minalrestat
Rendered image for Minalrestat
Gossylic lactone
Rendered image for Gossylic lactone
AZD1981
Rendered image for AZD1981
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
61.4
Agents acting on the renin-angiotensin system use measurement
1
1
1
39.6
response to diuretic
1
1
0
19.1
0
systolic blood pressure change measurement
1
1
0
19.1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
61.4
Agents acting on the renin-angiotensin system use measurement
1
39.6
response to diuretic
0
19.1
0
systolic blood pressure change measurement
0
19.1
0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member B
VGNC:13628
737737
Mouse
MGI:1353494
11677
Rat
RGD:2092
24192
Horse
aldo-keto reductase family 1 member B
VGNC:15214
100065145
Cow
aldo-keto reductase family 1, member B1 (aldose reductase)
317748
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member B
Mouse
Rat
Horse
aldo-keto reductase family 1 member B
Cow
aldo-keto reductase family 1, member B1 (aldose reductase)
Protein Structure (140 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15121-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 140
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Fructose biosynthesis (R-HSA-5652227)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fructose biosynthesis
Reactome
Fructose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fructose biosynthesis
Fructose metabolism
Metabolism
Metabolism of carbohydrates
Metabolism of lipids
Gene Ontology Terms (38)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (171)
1 – 10 of 171
AKR1B15
Tbio
Family:  Enzyme
Novelty:  0.29076067
p_int:  0.999929771
p_ni:  0.000070229
Score:  0.701
Data Source:  BioPlex,STRINGDB
SORD
Tchem
Family:  Enzyme
Novelty:  0.0040485
Score:  0.996
Data Source:  STRINGDB
DHDH
Tbio
Family:  Enzyme
Novelty:  0.00284827
Score:  0.96
Data Source:  STRINGDB
SPR
Tchem
Family:  Enzyme
Novelty:  0.02144934
Score:  0.957
Data Source:  STRINGDB
DHFR
Tclin
Family:  Enzyme
Novelty:  0.00074557
Score:  0.951
Data Source:  STRINGDB
DCXR
Tbio
Family:  Enzyme
Novelty:  0.00967328
Score:  0.94
Data Source:  STRINGDB
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
Score:  0.929
Data Source:  STRINGDB
QDPR
Tchem
Family:  Enzyme
Novelty:  0.00836889
Score:  0.929
Data Source:  STRINGDB
GALM
Tbio
Family:  Enzyme
Novelty:  0.01067063
Score:  0.928
Data Source:  STRINGDB
TPH1
Tclin
Family:  Enzyme
Novelty:  0.00098637
Score:  0.926
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2250.92

PubMed score by year
PubTator Score  1494.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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