Protein Summary
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
- ENST00000285930
- ENSP00000285930
- ENSG00000085662
- ALDR1
- AR
- ADR
- ALR2
- ALDR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.98 | ||
transcription factor perturbation | 0.97 | ||
drug | 0.96 | ||
chemical | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2250.92 (req: < 5)
Gene RIFs: 89 (req: <= 3)
Antibodies: 465 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2250.92 (req: >= 5)
Gene RIFs: 89 (req: > 3)
Antibodies: 465 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 490
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (490)
Protein-Protein Interactions (171)
AKR1B15
Family: Enzyme
Novelty: 0.29076067
p_int: 0.999929771
p_ni: 0.000070229
Score: 0.701
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (8)
KEGG (6)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fructose biosynthesis | ||||
Reactome | Fructose metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Reactome | Metabolism of lipids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fructose biosynthesis | ||||
Fructose metabolism | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Metabolism of lipids | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (5)
Components (10)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 1 | 1 | 61.4 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 39.6 | |||||
response to diuretic | 1 | 1 | 0 | 19.1 | 0 | ||||
systolic blood pressure change measurement | 1 | 1 | 0 | 19.1 | 0 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 61.4 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 39.6 | |||||
response to diuretic | 0 | 19.1 | 0 | ||||
systolic blood pressure change measurement | 0 | 19.1 | 0 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aldo-keto reductase family 1 member B | VGNC:13628 | 737737 | |||||
Mouse | MGI:1353494 | 11677 | ||||||
Rat | RGD:2092 | 24192 | ||||||
Horse | aldo-keto reductase family 1 member B | VGNC:15214 | 100065145 | |||||
Cow | aldo-keto reductase family 1, member B1 (aldose reductase) | 317748 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aldo-keto reductase family 1 member B | |||||
Mouse | ||||||
Rat | ||||||
Horse | aldo-keto reductase family 1 member B | |||||
Cow | aldo-keto reductase family 1, member B1 (aldose reductase) | |||||
Publication Statistics
PubMed Score 2250.92
PubMed score by year
PubTator Score 1494.53
PubTator score by year
Related Publications
Text Mined References (164)
GeneRif Annotations (89)
Items per page:
0 of 0
PMID | Year | Title |
|---|