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Tchem
FABP4
Fatty acid-binding protein, adipocyte

Protein Summary
Description
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256104
  • ENSP00000256104
  • ENSG00000170323

Symbol
  • aP2
  • ALBP
  • AFABP
  • A-FABP
  • HEL-S-104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.85
small molecule perturbation
0.85
biological process
0.84
transcription factor perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1049.99   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 754   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1049.99   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 754   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 121
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 4
VGNC:6679
464255
Mouse
MGI:88038
11770
Rat
RGD:69309
79451
Dog
fatty acid binding protein 4
608476
Horse
fatty acid-binding protein, adipocyte
100057425
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 4
Mouse
Rat
Dog
fatty acid binding protein 4
Horse
fatty acid-binding protein, adipocyte
Protein Structure (31 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15090-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 31
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Transcriptional regulation of white adipocyte differentiation
Reactome
Triglyceride catabolism
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
Transcriptional regulation of white adipocyte differentiation
Triglyceride catabolism
Protein-Protein Interactions (195)
1 – 10 of 195
GDF5
Tbio
Novelty: 0.00218118
p_int: 0.999999374
p_ni: 7.5e-8
p_wrong: 5.51e-7
Score: 0.242
Data Source: BioPlex,STRINGDB
OAZ3
Tbio
Family: Enzyme
Novelty: 0.02374168
p_int: 0.999998713
p_ni: 0.000001242
p_wrong: 4.5e-8
Score: 0.242
Data Source: BioPlex,STRINGDB
ATG101
Tbio
Novelty: 0.03407206
p_int: 0.795946595
p_ni: 0.000035418
p_wrong: 0.204017988
Data Source: BioPlex
PPARG
Tclin
Family: NR
Novelty: 0.00010033
Score: 0.991
Data Source: STRINGDB
ADIPOQ
Tbio
Novelty: 0.00011196
Score: 0.989
Data Source: STRINGDB
LIPE
Tchem
Family: Enzyme
Novelty: 0.00169872
Score: 0.981
Data Source: Reactome,STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.98
Data Source: STRINGDB
PLIN1
Tbio
Novelty: 0.00200378
Score: 0.973
Data Source: STRINGDB
CEBPA
Tbio
Family: TF
Novelty: 0.00056459
Score: 0.969
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  1049.99

PubMed score by year
PubTator Score  491.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer