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Tchem
CPB1
Carboxypeptidase B

Protein Summary
Description
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282957
  • ENSP00000282957
  • ENSG00000153002
  • ENST00000491148
  • ENSP00000417222

Symbol
  • CPB
  • PCPB
  • CPB
  • PASP
  • PCPB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
PubMedID
0.61
small molecule perturbation
0.59
tissue sample
0.58
cell line
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 858.12   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 858.12   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 35
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (67)
1 – 10 of 67
CTRL
Tchem
Family: Enzyme
Novelty: 0.00045495
Score: 0.96
Data Source: STRINGDB
CELA2A
Tbio
Family: Enzyme
Novelty: 0.14098356
Score: 0.945
Data Source: STRINGDB
AGT
Tbio
Novelty: 0.00049613
Score: 0.919
Data Source: STRINGDB
CELA3B
Tbio
Family: Enzyme
Novelty: 0.0039289
Score: 0.913
Data Source: STRINGDB
CELA2B
Tdark
Family: Enzyme
Novelty: 0.43122129
Score: 0.878
Data Source: STRINGDB
CTRC
Tchem
Family: Enzyme
Novelty: 0.00457428
Score: 0.877
Data Source: STRINGDB
CELA3A
Tbio
Family: Enzyme
Novelty: 0.04100319
Score: 0.877
Data Source: STRINGDB
CEL
Tchem
Family: Enzyme
Novelty: 0.00156761
Score: 0.846
Data Source: STRINGDB
CPA1
Tchem
Family: Enzyme
Novelty: 0.00601525
Score: 0.844
Data Source: STRINGDB
PNLIP
Tclin
Family: Enzyme
Novelty: 0.00043254
Score: 0.843
Data Source: STRINGDB
Publication Statistics
PubMed Score  858.12

PubMed score by year
PubTator Score  514.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer