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Tchem
CPA1
Carboxypeptidase A1

Protein Summary
Description
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000011292
  • ENSP00000011292
  • ENSG00000091704

Symbol
  • CPA
  • CPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.68
hub protein
0.58
tissue sample
0.58
disease perturbation
0.56
molecular function
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
1
1.1
52.5
BMI-adjusted waist-hip ratio
1
1
1
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
52.5
BMI-adjusted waist-hip ratio
1
42.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase A1
VGNC:4316
100614351
Macaque
carboxypeptidase A1
703095
Mouse
MGI:88478
109697
Rat
RGD:2388
24269
Dog
carboxypeptidase A1
VGNC:39543
475192
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase A1
Macaque
carboxypeptidase A1
Mouse
Rat
Dog
carboxypeptidase A1
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (60)
1 – 10 of 60
CELA3B
Tbio
Family: Enzyme
Novelty: 0.0039289
Score: 0.979
Data Source: STRINGDB
CELA3A
Tbio
Family: Enzyme
Novelty: 0.04100319
Score: 0.969
Data Source: STRINGDB
CTRL
Tchem
Family: Enzyme
Novelty: 0.00045495
Score: 0.961
Data Source: STRINGDB
CTRC
Tchem
Family: Enzyme
Novelty: 0.00457428
Score: 0.952
Data Source: STRINGDB
CTRB1
Tchem
Family: Enzyme
Novelty: 0.01637745
Score: 0.945
Data Source: STRINGDB
CEL
Tchem
Family: Enzyme
Novelty: 0.00156761
Score: 0.919
Data Source: STRINGDB
CTRB2
Tdark
Family: Enzyme
Novelty: 0.20557479
Score: 0.918
Data Source: STRINGDB
CELA2A
Tbio
Family: Enzyme
Novelty: 0.14098356
Score: 0.871
Data Source: STRINGDB
CPA2
Tbio
Family: Enzyme
Novelty: 0.01066441
Score: 0.867
Data Source: STRINGDB
CPB1
Tchem
Family: Enzyme
Novelty: 0.00108031
Score: 0.844
Data Source: STRINGDB
Publication Statistics
PubMed Score  162.32

PubMed score by year
PubTator Score  253.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer