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Tbio
ETS2
Protein C-ets-2

Protein Summary
Description
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360214
  • ENSP00000353344
  • ENSG00000157557
  • ENST00000360938
  • ENSP00000354194

Symbol
  • ETS2IT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
transcription factor binding site profile
0.93
PubMedID
0.92
molecular function
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.16   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.16   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
2
2
59.7
body mass index
3
2
3
46.8
body height
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
2
59.7
body mass index
3
46.8
body height
1
5.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ETS proto-oncogene 2, transcription factor
VGNC:8281
473996
Macaque
ETS proto-oncogene 2, transcription factor
715887
Mouse
MGI:95456
23872
Rat
RGD:1584977
304063
Dog
ETS proto-oncogene 2, transcription factor
VGNC:40495
487761
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ETS proto-oncogene 2, transcription factor
Macaque
ETS proto-oncogene 2, transcription factor
Mouse
Rat
Dog
ETS proto-oncogene 2, transcription factor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15036-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oncogene Induced Senescence
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Oncogene Induced Senescence
Gene Ontology Terms (20)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (104)
1 – 10 of 104
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.986
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.963
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.943
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.941
Data Source:  Reactome,STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.94
Data Source:  Reactome,STRINGDB
CEBPA
Tbio
Family:  TF
Novelty:  0.00056459
Score:  0.939
Data Source:  STRINGDB
ID1
Tbio
Family:  TF
Novelty:  0.00151069
Score:  0.938
Data Source:  Reactome,STRINGDB
ETS1
Tbio
Family:  TF
Novelty:  0.00105233
Score:  0.93
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.926
Data Source:  STRINGDB
SP1
Tbio
Family:  TF
Novelty:  0.0007915
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  303.16

PubMed score by year
PubTator Score  197.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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