Protein Summary
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif cal ...more
- ENST00000310706
- ENSP00000311113
- ENSG00000173801
- ENST00000393930
- ENSP00000377507
- ENST00000393931
- ENSP00000377508
- CTNNG
- DP3
- DP3
- PDGB
- PKGB
- CTNNG
- DPIII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.99 | ||
biological process | 0.97 | ||
molecular function | 0.91 | ||
transcription factor binding site profile | 0.9 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.24 (req: < 5)
Gene RIFs: 79 (req: <= 3)
Antibodies: 1171 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.24 (req: >= 5)
Gene RIFs: 79 (req: > 3)
Antibodies: 1171 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (238)
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.989837873
p_ni: 0.010162127
Score: 0.241
Data Source: BioPlex,STRINGDB
GPATCH2L
Novelty: 1.68490464
p_int: 0.980625237
p_ni: 0.019374763
Score: 0.171
Data Source: BioPlex,STRINGDB
CDH8
Novelty: 0.04055999
p_int: 0.967017883
p_ni: 0.032982117
Score: 0.93
Data Source: BioPlex,STRINGDB
NPPA
Novelty: 0.00046693
p_int: 0.946100043
p_ni: 0.053899957
Score: 0.169
Data Source: BioPlex,STRINGDB
RAD51AP1
Novelty: 0.04859066
p_int: 0.915980396
p_ni: 0.084019604
Score: 0.295
Data Source: BioPlex,STRINGDB
PDE4DIP
Novelty: 0.03414104
p_int: 0.907444717
p_ni: 0.092555283
Score: 0.156
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (6)
Upstream (1)
Downstream (5)
1 – 1 of 1
Pathways (33)
Reactome (15)
KEGG (5)
PathwayCommons (8)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adherens junctions interactions | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adherens junctions interactions | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Developmental Biology | ||||
Viral Interactions (0)
Gene Ontology Terms (61)
Functions (11)
Components (26)
Processes (24)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 3 | 4 | 94.7 | |||||
reticulocyte count | 5 | 3 | 5 | 94.3 | |||||
heel bone mineral density | 3 | 2 | 4 | 78.7 | |||||
balding measurement | 1 | 1 | 1 | 64.4 | |||||
eosinophil count | 2 | 1 | 2 | 48.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 4 | 94.7 | |||||
reticulocyte count | 5 | 94.3 | |||||
heel bone mineral density | 4 | 78.7 | |||||
balding measurement | 1 | 64.4 | |||||
eosinophil count | 2 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | junction plakoglobin | VGNC:12316 | 454667 | |||||
Macaque | junction plakoglobin | 707769 | ||||||
Mouse | MGI:96650 | 16480 | ||||||
Rat | RGD:620412 | 81679 | ||||||
Dog | junction plakoglobin | 480522 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | junction plakoglobin | |||||
Macaque | junction plakoglobin | |||||
Mouse | ||||||
Rat | ||||||
Dog | junction plakoglobin | |||||
Publication Statistics
PubMed Score 106.24
PubMed score by year
PubTator Score 46.70
PubTator score by year
Related Publications
Text Mined References (160)
GeneRif Annotations (79)
Items per page:
0 of 0
PMID | Year | Title |
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