Tbio JUP Junction plakoglobin

Protein Summary

Description

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P14923
• Q15093
• Q15151
• Q7L3S5
• Q86W21
• Q9BWC4
• Q9HCX9

Gene Name

• JUP

Ensembl ID

• ENST00000310706
• ENSP00000311113
• ENSG00000173801
• ENST00000393930
• ENSP00000377507
• ENST00000393931
• ENSP00000377508

Symbol

• CTNNG
• DP3
• DP3
• PDGB
• PKGB
• CTNNG
• DPIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
biological process	0.97
molecular function	0.91
transcription factor binding site profile	0.9
ligand (protein) perturbation	0.83

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.24   (req: < 5)

Gene RIFs: 79   (req: <= 3)

Antibodies: 1171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.24   (req: >= 5)

Gene RIFs: 79   (req: > 3)

Antibodies: 1171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3	3	4		94.7
reticulocyte count	EFO_0007986	5	3	5		94.3
heel bone mineral density	EFO_0009270	3	2	4		78.7
balding measurement	EFO_0007825	1	1	1		64.4
eosinophil count	EFO_0004842	2	1	2		48.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	4		94.7
reticulocyte count	EFO_0007986	5		94.3
heel bone mineral density	EFO_0009270	4		78.7
balding measurement	EFO_0007825	1		64.4
eosinophil count	EFO_0004842	2		48.5

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	junction plakoglobin	VGNC:12316	454667
Macaque	junction plakoglobin		707769
Mouse	junction plakoglobin	MGI:96650	16480
Rat	junction plakoglobin	RGD:620412	81679
Dog	junction plakoglobin		480522

Species	Name	OMA	EggNOG	Inparanoid
Chimp	junction plakoglobin
Macaque	junction plakoglobin
Mouse	junction plakoglobin
Rat	junction plakoglobin
Dog	junction plakoglobin

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14923-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (33)

Reactome (15)

KEGG (5)

PathwayCommons (8)

WikiPathways (5)

Adherens junctions interactions (R-HSA-418990)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adherens junctions interactions	31 targets	R-HSA-418990
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Name	Explore in Pharos	Explore in Source
Adherens junctions interactions	31 targets	R-HSA-418990
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Developmental Biology	1055 targets	R-HSA-1266738

Gene Ontology Terms (61)

Functions (11)

Components (26)

Processes (24)

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Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
transcription coactivator activity	Inferred from Direct Assay (IDA)	BHF-UCL
alpha-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cadherin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cell adhesion molecule binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein phosphatase binding	Inferred from Physical Interaction (IPI)	UniProtKB
nuclear hormone receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein homodimerization activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
structural molecule activity	Non-traceable Author Statement (NAS)	BHF-UCL
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	Inferred by Curator (IC)	BHF-UCL
structural constituent of cell wall	Inferred by Curator (IC)	BHF-UCL

Protein-Protein Interactions (238)

Explore Interacting Targets

1 – 10 of 238

• See Interactions on String-DB

CCDC51

Tdark

Novelty:  1.19203634

p_int:  0.997899691

p_ni:  0.002100309

Data Source:  BioPlex

PI4KA

Tchem

Family:  Kinase

Novelty:  0.01701469

p_int:  0.989837873

p_ni:  0.010162127

Score:  0.241

Data Source:  BioPlex,STRINGDB

GPATCH2L

Tdark

Novelty:  1.68490464

p_int:  0.980625237

p_ni:  0.019374763

Score:  0.171

Data Source:  BioPlex,STRINGDB

GMCL1

Tbio

Novelty:  0.1543762

p_int:  0.973554728

p_ni:  0.026445272

Data Source:  BioPlex

CDH8

Tbio

Novelty:  0.04055999

p_int:  0.967017883

p_ni:  0.032982117

Score:  0.93

Data Source:  BioPlex,STRINGDB

NPPA

Tchem

Novelty:  0.00046693

p_int:  0.946100043

p_ni:  0.053899957

Score:  0.169

Data Source:  BioPlex,STRINGDB

KLHL11

Tbio

Novelty:  0.1537041

p_int:  0.935745446

p_ni:  0.064254554

Data Source:  BioPlex

RAD51AP1

Tbio

Novelty:  0.04859066

p_int:  0.915980396

p_ni:  0.084019604

Score:  0.295

Data Source:  BioPlex,STRINGDB

PDE4DIP

Tbio

Novelty:  0.03414104

p_int:  0.907444717

p_ni:  0.092555283

Score:  0.156

Data Source:  BioPlex,STRINGDB

OAZ3

Tbio

Family:  Enzyme

Novelty:  0.02374168

p_int:  0.77165695

p_ni:  0.22834305

Data Source:  BioPlex

Publication Statistics

PubMed Score  106.24

PubMed score by year

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PubTator Score  46.7

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cardiomyopathy
Cell adhesion
Cell junction
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
eosinophil count
esophageal carcinoma
HbA1c measurement
heel bone mineral density
reticulocyte count
reticulocyte measurement
squamous cell carcinoma
viral load

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype