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Tbio
JUP
Junction plakoglobin

Protein Summary
Description
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif cal ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310706
  • ENSP00000311113
  • ENSG00000173801
  • ENST00000393930
  • ENSP00000377507
  • ENST00000393931
  • ENSP00000377508

Symbol
  • CTNNG
  • DP3
  • DP3
  • PDGB
  • PKGB
  • CTNNG
  • DPIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
biological process
0.97
molecular function
0.91
transcription factor binding site profile
0.9
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.24   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 1171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.24   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 1171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
3
4
94.7
reticulocyte count
5
3
5
94.3
heel bone mineral density
3
2
4
78.7
balding measurement
1
1
1
64.4
eosinophil count
2
1
2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
4
94.7
reticulocyte count
5
94.3
heel bone mineral density
4
78.7
balding measurement
1
64.4
eosinophil count
2
48.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
junction plakoglobin
VGNC:12316
454667
Macaque
junction plakoglobin
707769
Mouse
MGI:96650
16480
Rat
RGD:620412
81679
Dog
junction plakoglobin
480522
Species
Name
OMA
EggNOG
Inparanoid
Chimp
junction plakoglobin
Macaque
junction plakoglobin
Mouse
Rat
Dog
junction plakoglobin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14923-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Developmental Biology
Gene Ontology Terms (61)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred by Curator (IC)
BHF-UCL
Inferred by Curator (IC)
BHF-UCL
Protein-Protein Interactions (238)
1 – 10 of 238
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.997899691
p_ni:  0.002100309
Data Source:  BioPlex
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.989837873
p_ni:  0.010162127
Score:  0.241
Data Source:  BioPlex,STRINGDB
GPATCH2L
Tdark
Novelty:  1.68490464
p_int:  0.980625237
p_ni:  0.019374763
Score:  0.171
Data Source:  BioPlex,STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.973554728
p_ni:  0.026445272
Data Source:  BioPlex
CDH8
Tbio
Novelty:  0.04055999
p_int:  0.967017883
p_ni:  0.032982117
Score:  0.93
Data Source:  BioPlex,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.946100043
p_ni:  0.053899957
Score:  0.169
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.935745446
p_ni:  0.064254554
Data Source:  BioPlex
RAD51AP1
Tbio
Novelty:  0.04859066
p_int:  0.915980396
p_ni:  0.084019604
Score:  0.295
Data Source:  BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.907444717
p_ni:  0.092555283
Score:  0.156
Data Source:  BioPlex,STRINGDB
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.77165695
p_ni:  0.22834305
Data Source:  BioPlex
Publication Statistics
PubMed Score  106.24

PubMed score by year
PubTator Score  46.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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