Tbio ETS1 Protein C-ets-1

Protein Summary

Description

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• P14921
• A9UL17
• F5GYX9
• Q14278
• Q16080
• Q6N087
• Q96AC5

Gene Name

• ETS1

Ensembl ID

• ENST00000319397
• ENSP00000324578
• ENSG00000134954
• ENST00000392668
• ENSP00000376436
• ENST00000526145
• ENSP00000433500
• ENST00000531611
• ENSP00000435666
• ENST00000535549
• ENSP00000441430

Symbol

• EWSR2
• p54
• ETS-1
• EWSR2
• c-ets-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
transcription factor perturbation	0.98
biological process	0.95
hub protein	0.95
biological term	0.86

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein C-ets-1

Protein / Signaling Molecule / Protein C-ets-1

Protein / Nucleic Acid Binding / Protein C-ets-1

Protein / ... / Winged Helix/forkhead Transcription Factor / Protein C-ets-1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Protein C-ets-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1011.22   (req: < 5)

Gene RIFs: 348   (req: <= 3)

Antibodies: 674   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1011.22   (req: >= 5)

Gene RIFs: 348   (req: > 3)

Antibodies: 674   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0