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Tbio
ETS1
Protein C-ets-1

Protein Summary
Description
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319397
  • ENSP00000324578
  • ENSG00000134954
  • ENST00000392668
  • ENSP00000376436
  • ENST00000526145
  • ENSP00000433500
  • ENST00000531611
  • ENSP00000435666
  • ENST00000535549
  • ENSP00000441430

Symbol
  • EWSR2
  • p54
  • ETS-1
  • EWSR2
  • c-ets-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
transcription factor perturbation
0.98
biological process
0.95
hub protein
0.95
biological term
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 933.71   (req: < 5)
Gene RIFs: 270   (req: <= 3)
Antibodies: 674   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 933.71   (req: >= 5)
Gene RIFs: 270   (req: > 3)
Antibodies: 674   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
2
5
91.1
monocyte count
3
4
4
88.8
4
3
1
1.2
86.8
myeloid white cell count
2
1
2
82.4
2
1
0
1.3
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
91.1
monocyte count
4
88.8
1
1.2
86.8
myeloid white cell count
2
82.4
0
1.3
82.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ETS proto-oncogene 1, transcription factor
VGNC:8163
451695
Macaque
ETS proto-oncogene 1, transcription factor
714697
Mouse
MGI:95455
23871
Rat
RGD:2583
24356
Dog
ETS proto-oncogene 1, transcription factor
VGNC:40494
489287
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ETS proto-oncogene 1, transcription factor
Macaque
ETS proto-oncogene 1, transcription factor
Mouse
Rat
Dog
ETS proto-oncogene 1, transcription factor
Protein Data Bank (21)
1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oncogene Induced Senescence
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Oncogene Induced Senescence
Gene Ontology Terms (49)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (247)
1 – 10 of 247
PAX5
Tbio
Family: TF
Novelty: 0.0012666
Score: 0.988
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.987
Data Source: Reactome,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.985
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
Score: 0.982
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
Score: 0.974
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.971
Data Source: Reactome,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.969
Data Source: STRINGDB
SP1
Tbio
Family: TF
Novelty: 0.0007915
Score: 0.964
Data Source: STRINGDB
STAT6
Tchem
Family: TF
Novelty: 0.00096732
Score: 0.96
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  933.71

PubMed score by year
PubTator Score  660.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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