Tchem IDO1 Indoleamine 2,3-dioxygenase 1

Protein Summary

Description

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P14902
• E5RGR8
• F6M9T7
• Q540B4
• IDO-1

Gene Name

• IDO1

Ensembl ID

• ENST00000518237
• ENSP00000430950
• ENSG00000131203
• ENST00000522495
• ENSP00000430505

Symbol

• IDO
• INDO
• IDO
• INDO
• IDO-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
virus perturbation	0.94
PubMedID	0.81
cell type or tissue	0.76
gene perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1343.42   (req: < 5)

Gene RIFs: 465   (req: <= 3)

Antibodies: 855   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1343.42   (req: >= 5)

Gene RIFs: 465   (req: > 3)

Antibodies: 855   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1150

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1