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Tbio
DARS
Aspartate--tRNA ligase, cytoplasmic

Protein Summary
Description
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.97
protein domain
0.92
disease perturbation
0.87
histone modification site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.32   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.32   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
88.3
myeloid white cell count
1
1
1
82.8
monocyte count
2
2
2
76.6
leukocyte count
1
1
1
57.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
88.3
myeloid white cell count
1
82.8
monocyte count
2
76.6
leukocyte count
1
57.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aspartyl-tRNA synthetase
VGNC:10739
459634
Macaque
aspartyl-tRNA synthetase
707449
Mouse
MGI:2442544
226414
Rat
RGD:621167
116483
Dog
aspartyl-tRNA synthetase
VGNC:39774
476132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aspartyl-tRNA synthetase
Macaque
aspartyl-tRNA synthetase
Mouse
Rat
Dog
aspartyl-tRNA synthetase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14868-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (46)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (132)
1 – 10 of 132
RARS
Tchem
Family: Enzyme
Novelty: 0.00099479
p_int: 0.999528633
p_ni: 0.000471367
Score: 0.996
Data Source: BioPlex,STRINGDB
KARS
Tchem
Family: Enzyme
Novelty: 0.00386511
p_int: 0.999149756
p_ni: 0.000850244
Score: 0.994
Data Source: BioPlex,STRINGDB
AIMP1
Tbio
Family: Enzyme
Novelty: 0.00743447
p_int: 0.993483975
p_ni: 0.006516025
Score: 0.996
Data Source: BioPlex,STRINGDB
LARS
Tchem
Family: Enzyme
Novelty: 0.00361711
p_int: 0.990205531
p_ni: 0.009794469
Score: 0.998
Data Source: BioPlex,STRINGDB
QARS
Tchem
Family: Enzyme
Novelty: 0.01684657
p_int: 0.989075671
p_ni: 0.010924329
Score: 0.997
Data Source: BioPlex,STRINGDB
SDCBP
Tbio
Novelty: 0.00242211
p_int: 0.983480748
p_ni: 0.016519252
Score: 0.817
Data Source: BioPlex,STRINGDB
SYNJ2BP
Tbio
Novelty: 0.02520087
p_int: 0.860158517
p_ni: 0.139841483
Data Source: BioPlex
COMTD1
Tdark
Family: Enzyme
Novelty: 0.245971
p_int: 0.839500143
p_ni: 0.160499857
Score: 0.161
Data Source: BioPlex,STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.999
Data Source: STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  93.32

PubMed score by year
PubTator Score  20.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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