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Tbio
HNRNPL
Heterogeneous nuclear ribonucleoprotein L

Protein Summary
Description
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221419
  • ENSP00000221419
  • ENSG00000104824
  • ENST00000600873
  • ENSP00000470231
  • ENST00000634237
  • ENSP00000489244
  • ENSG00000282947
  • ENST00000634753
  • ENSP00000489021

Symbol
  • HNRPL
  • HNRPL
  • hnRNP-L
  • P/OKcl.14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
transcription factor binding site profile
0.96
transcription factor
0.93
hub protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.18   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 396   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.18   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 396   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (325)
1 – 10 of 325
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.845338377
p_ni:  0.154661623
Score:  0.959
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.789028906
p_ni:  0.210971094
Score:  0.575
Data Source:  BioPlex,STRINGDB
HNRNPA0
Tbio
Novelty:  0.10233768
Score:  0.999
Data Source:  STRINGDB
HNRNPC
Tbio
Novelty:  0.00136097
Score:  0.999
Data Source:  STRINGDB
PTBP1
Tbio
Novelty:  0.00184728
Score:  0.999
Data Source:  STRINGDB
HNRNPK
Tbio
Novelty:  0.00354731
Score:  0.999
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.999
Data Source:  STRINGDB
HNRNPA2B1
Tbio
Novelty:  0.00404935
Score:  0.999
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.999
Data Source:  STRINGDB
SRSF1
Tbio
Novelty:  0.00074446
Score:  0.998
Data Source:  STRINGDB
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
89.6
platelet count
2
2
2
89.6
SIR2-like protein 2 measurement
1
1
1
81.1
SIR2-like protein 2 measurement
1
1
1
81.1
platelet crit
1
1
1
66.8
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
89.6
platelet count
2
89.6
SIR2-like protein 2 measurement
1
81.1
SIR2-like protein 2 measurement
1
81.1
platelet crit
1
66.8
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein L
VGNC:2342
456012
Macaque
heterogeneous nuclear ribonucleoprotein L
694448
Mouse
MGI:104816
15388
Rat
RGD:71059
80846
Dog
heterogeneous nuclear ribonucleoprotein L
100855936
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein L
Macaque
heterogeneous nuclear ribonucleoprotein L
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein L
Publication Statistics
PubMed Score 107.18
PubMed score by year
PubTator Score 63.60
PubTator score by year