Tbio COX6B1 Cytochrome c oxidase subunit 6B1

Protein Summary

Description

Connects the two COX monomers into the physiological dimeric form. Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P14854
• B2R5C9
• Q6IBL4

Gene Name

• COX6B1

Ensembl ID

• ENST00000246554
• ENSP00000246554
• ENSG00000126267
• ENST00000392201
• ENSP00000376037
• ENST00000592141
• ENSP00000466818
• ENST00000649813
• ENSP00000497926

Symbol

• COX6B
• COXG
• COX6B
• COXVIb1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
disease perturbation	0.79
co-expressed gene	0.76
gene perturbation	0.74
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.78   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 279   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.78   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0