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Tclin
IL1R1
Interleukin-1 receptor type 1

Protein Summary
Description
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of rel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000410023
  • ENSP00000386380
  • ENSG00000115594

Symbol
  • IL1R
  • IL1RA
  • IL1RT1
  • P80
  • IL1R
  • IL1RA
  • CD121A
  • D2S1473
  • IL-1R-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.97
disease
0.9
phenotype
0.81
small molecule perturbation
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.32   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 845   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.32   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 845   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
anakinra
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
3
3
95.8
serum ST2 measurement
1
1
1
83.8
fibrinogen measurement
4
2
4
64.7
albumin:globulin ratio measurement
1
1
1
16.2
1
1
0
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
95.8
serum ST2 measurement
1
83.8
fibrinogen measurement
4
64.7
albumin:globulin ratio measurement
1
16.2
0
1
7.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interleukin 1 receptor type 1
711726
Mouse
MGI:96545
16177
Rat
RGD:2892
25663
Dog
interleukin 1 receptor type 1
VGNC:41958
481328
Horse
interleukin 1 receptor type 1
VGNC:19008
100009699
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interleukin 1 receptor type 1
Mouse
Rat
Dog
interleukin 1 receptor type 1
Horse
interleukin 1 receptor type 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14778-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (116)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Reactome
Interleukin-10 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Interleukin-10 signaling
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (201)
1 – 10 of 201
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
p_int: 0.969442861
p_ni: 0.030557139
Data Source: BioPlex
ICK
Tchem
Family: Kinase
Novelty: 0.00810476
p_int: 0.930508911
p_ni: 0.001787409
p_wrong: 0.06770368
Score: 0.189
Data Source: BioPlex,STRINGDB
TUBB8
Tclin
Novelty: 0.06403117
p_int: 0.883030189
p_ni: 0.116969811
Data Source: BioPlex
MFAP3
Tdark
Novelty: 0.55512255
p_int: 0.876842001
p_ni: 0.123157998
Score: 0.51
Data Source: BioPlex,STRINGDB
TNFRSF10B
Tbio
Novelty: 0.00054433
p_int: 0.849323484
p_ni: 0.15033393
p_wrong: 0.000342586
Score: 0.404
Data Source: BioPlex,STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
p_int: 0.817128508
p_ni: 0.086153516
p_wrong: 0.096717975
Score: 0.2
Data Source: BioPlex,STRINGDB
IRAK4
Tchem
Family: Kinase
Novelty: 0.00344058
Score: 0.999
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.999
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.999
Data Source: Reactome,STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  574.32

PubMed score by year
PubTator Score  397.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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