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Tclin
IL1R1
Interleukin-1 receptor type 1

Protein Summary
Description
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of rel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000410023
  • ENSP00000386380
  • ENSG00000115594

Symbol
  • IL1R
  • IL1RA
  • IL1RT1
  • P80
  • IL1R
  • IL1RA
  • CD121A
  • D2S1473
  • IL-1R-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.97
disease
0.9
phenotype
0.81
small molecule perturbation
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 594.4   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 845   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 594.4   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 845   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (201)
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.969442861
p_ni:  0.030557139
Data Source:  BioPlex
ICK
Tchem
Family:  Kinase
Novelty:  0.00810476
p_int:  0.930508911
p_ni:  0.001787409
p_wrong:  0.06770368
Score:  0.189
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.883030189
p_ni:  0.116969811
Data Source:  BioPlex
MFAP3
Tdark
Novelty:  0.55512255
p_int:  0.876842001
p_ni:  0.123157998
Score:  0.51
Data Source:  BioPlex,STRINGDB
TNFRSF10B
Tbio
Novelty:  0.00054433
p_int:  0.849323484
p_ni:  0.15033393
p_wrong:  0.000342586
Score:  0.404
Data Source:  BioPlex,STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.817128508
p_ni:  0.086153516
p_wrong:  0.096717975
Score:  0.2
Data Source:  BioPlex,STRINGDB
IRAK4
Tchem
Family:  Kinase
Novelty:  0.00344058
Score:  0.999
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.999
Data Source:  Reactome,STRINGDB
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.999
Data Source:  Reactome,STRINGDB
MYD88
Tbio
Novelty:  0.00037931
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (116)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Reactome
Interleukin-10 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Interleukin-10 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
0
1.2
97
age at onset
1
3
0
1.2
89.1
serum ST2 measurement
1
3
3
87.9
childhood onset asthma
1
2
0
1.2
86.3
C-reactive protein measurement
3
3
3
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
97
age at onset
0
1.2
89.1
serum ST2 measurement
3
87.9
childhood onset asthma
0
1.2
86.3
C-reactive protein measurement
3
85.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interleukin 1 receptor type 1
711726
Mouse
MGI:96545
16177
Rat
RGD:2892
25663
Dog
interleukin 1 receptor type 1
VGNC:41958
481328
Horse
interleukin 1 receptor type 1
VGNC:19008
100009699
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interleukin 1 receptor type 1
Mouse
Rat
Dog
interleukin 1 receptor type 1
Horse
interleukin 1 receptor type 1
Publication Statistics
PubMed Score 594.40
PubMed score by year
PubTator Score 397.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title