You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GP9
Platelet glycoprotein IX

Protein Summary
Description
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307395
  • ENSP00000303942
  • ENSG00000169704

Symbol
  • GPIX
  • CD42a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
tissue
0.63
biological term
0.54
gene perturbation
0.52
cell line
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.76   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 480   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.76   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
82.8
platelet count
1
1
1
52.7
platelet crit
1
1
1
30.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
82.8
platelet count
1
52.7
platelet crit
1
30.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycoprotein IX platelet
VGNC:9464
737968
Macaque
glycoprotein IX platelet
704202
Mouse
MGI:1860137
54368
Rat
RGD:1561601
502858
Dog
glycoprotein IX platelet
VGNC:41357
609630
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycoprotein IX platelet
Macaque
glycoprotein IX platelet
Mouse
Rat
Dog
glycoprotein IX platelet
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14770-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
GP1b-IX-V activation signalling
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Reactome
Platelet Adhesion to exposed collagen
Name
Explore in Pharos
Explore in Source
Formation of Fibrin Clot (Clotting Cascade)
GP1b-IX-V activation signalling
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Platelet Adhesion to exposed collagen
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (87)
1 – 10 of 87
FZD6
Tbio
Family: GPCR
Novelty: 0.01425136
p_int: 0.999888777
p_ni: 0.000104114
p_wrong: 0.000007109
Data Source: BioPlex
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
p_int: 0.999325995
p_ni: 0.000125204
p_wrong: 0.000548801
Data Source: BioPlex
GLRB
Tclin
Family: IC
Novelty: 0.01721113
p_int: 0.998537705
p_ni: 0.001360924
p_wrong: 0.000101371
Data Source: BioPlex
LEMD3
Tbio
Novelty: 0.00579701
p_int: 0.998486385
p_ni: 0.001513614
Data Source: BioPlex
DPY19L4
Tdark
Family: Enzyme
Novelty: 0.99997412
p_int: 0.998260748
p_ni: 0.00173631
p_wrong: 0.000002942
Data Source: BioPlex
EPHA7
Tchem
Family: Kinase
Novelty: 0.01065563
p_int: 0.993681985
p_ni: 0.006318015
Data Source: BioPlex
FAM69A
Tdark
Novelty: 0.35978059
p_int: 0.97183917
p_ni: 0.028156669
p_wrong: 0.00000416
Data Source: BioPlex
LRRC8A
Tbio
Novelty: 0.0163093
p_int: 0.962285693
p_ni: 0.037714001
p_wrong: 3.06e-7
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.929471311
p_ni: 0.070528689
Data Source: BioPlex
TMEM39B
Tdark
Novelty: 3.99024108
p_int: 0.929233989
p_ni: 0.070071488
p_wrong: 0.000694523
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  254.76

PubMed score by year
PubTator Score  131.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer