Protein Classes
Protein Summary
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV). This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have no ...more
- ENST00000265986
- ENSP00000265986
- ENSG00000119912
- ENST00000371581
- ENSP00000360637
- INSULYSIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
transcription factor perturbation | 0.88 | ||
cellular component | 0.86 | ||
kinase perturbation | 0.84 | ||
biological term | 0.83 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 492.83 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 458 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 492.83 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 458 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 31
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (31)
1 – 10 of 31
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
survival time | 1 | 1 | 1 | 53.2 | |||||
sporadic amyotrophic lateral sclerosis | 1 | 1 | 1 | 53.2 | |||||
triglyceride measurement | 1 | 1 | 1 | 22.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
survival time | 1 | 53.2 | |||||
sporadic amyotrophic lateral sclerosis | 1 | 53.2 | |||||
triglyceride measurement | 1 | 22.9 | |||||
Protein Data Bank (50)
1 – 5 of 50
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (8)
Reactome (6)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Peroxisomal protein import | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deubiquitination | ||||
Metabolism of proteins | ||||
Peroxisomal protein import | ||||
Post-translational protein modification | ||||
Protein localization | ||||
Gene Ontology Terms (43)
Functions (13)
Components (11)
Processes (19)
Items per page:
10
1 – 10 of 13
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (183)
1 – 10 of 183
LYPD6B
Novelty: 0.1409054
p_int: 0.999774099
p_ni: 0.000225901
Data Source: BioPlex
HOXC9
Family: TF
Novelty: 0.02524418
p_int: 0.997698709
p_ni: 0.002301291
Score: 0.534
Data Source: BioPlex,STRINGDB
RPGR
Family: Enzyme
Novelty: 0.002733
p_int: 0.993263001
p_ni: 0.006736998
Score: 0.184
Data Source: BioPlex,STRINGDB
SPINK2
Family: Enzyme
Novelty: 0.06832697
p_int: 0.989303591
p_ni: 0.010696409
Data Source: BioPlex
PPP1R32
Family: Enzyme
Novelty: 0.38056479
p_int: 0.986172915
p_ni: 0.013827085
Score: 0.237
Data Source: BioPlex,STRINGDB
FAM19A3
Novelty: 0.37183557
p_int: 0.975295547
p_ni: 0.024704453
Data Source: BioPlex
CTAGE5
Novelty: 0.04516631
p_int: 0.969982198
p_ni: 0.030017802
Data Source: BioPlex
TINAG
Novelty: 0.04582927
p_int: 0.964482914
p_ni: 0.035517086
Data Source: BioPlex
ARSG
Family: Enzyme
Novelty: 0.04412917
p_int: 0.94377418
p_ni: 0.05622582
Data Source: BioPlex
CCL3L1
Novelty: 0.01124082
p_int: 0.93965188
p_ni: 0.06034812
Data Source: BioPlex
Publication Statistics
PubMed Score 492.83
PubMed score by year
PubTator Score 509.01
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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