Tchem IDE Insulin-degrading enzyme

Protein Summary

Description

Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV). This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P14735
• B2R721
• B7ZAU2
• D3DR35
• Q5T5N2

Gene Name

• IDE

Ensembl ID

• ENST00000265986
• ENSP00000265986
• ENSG00000119912
• ENST00000371581
• ENSP00000360637

Symbol

• INSULYSIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
transcription factor perturbation	0.88
cellular component	0.86
kinase perturbation	0.84
biological term	0.83

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Insulin-degrading Enzyme

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Insulin-degrading Enzyme

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.15   (req: < 5)

Gene RIFs: 113   (req: <= 3)

Antibodies: 458   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.15   (req: >= 5)

Gene RIFs: 113   (req: > 3)

Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 38

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0