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Tchem
IDE
Insulin-degrading enzyme

Protein Summary
Description
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus (VZV). This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have no ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265986
  • ENSP00000265986
  • ENSG00000119912
  • ENST00000371581
  • ENSP00000360637

Symbol
  • INSULYSIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
0.88
cellular component
0.86
kinase perturbation
0.84
biological term
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 492.83   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 492.83   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
survival time
1
1
1
53.2
sporadic amyotrophic lateral sclerosis
1
1
1
53.2
triglyceride measurement
1
1
1
22.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
survival time
1
53.2
sporadic amyotrophic lateral sclerosis
1
53.2
triglyceride measurement
1
22.9
Protein Data Bank (50)
1 – 5 of 50
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Peroxisomal protein import
Reactome
Post-translational protein modification
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Peroxisomal protein import
Post-translational protein modification
Protein localization
Gene Ontology Terms (43)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (183)
1 – 10 of 183
LYPD6B
Tdark
Novelty: 0.1409054
p_int: 0.999774099
p_ni: 0.000225901
Data Source: BioPlex
HOXC9
Tbio
Family: TF
Novelty: 0.02524418
p_int: 0.997698709
p_ni: 0.002301291
Score: 0.534
Data Source: BioPlex,STRINGDB
RPGR
Tbio
Family: Enzyme
Novelty: 0.002733
p_int: 0.993263001
p_ni: 0.006736998
Score: 0.184
Data Source: BioPlex,STRINGDB
SPINK2
Tdark
Family: Enzyme
Novelty: 0.06832697
p_int: 0.989303591
p_ni: 0.010696409
Data Source: BioPlex
PPP1R32
Tdark
Family: Enzyme
Novelty: 0.38056479
p_int: 0.986172915
p_ni: 0.013827085
Score: 0.237
Data Source: BioPlex,STRINGDB
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.975295547
p_ni: 0.024704453
Data Source: BioPlex
CTAGE5
Tbio
Novelty: 0.04516631
p_int: 0.969982198
p_ni: 0.030017802
Data Source: BioPlex
TINAG
Tbio
Novelty: 0.04582927
p_int: 0.964482914
p_ni: 0.035517086
Data Source: BioPlex
ARSG
Tbio
Family: Enzyme
Novelty: 0.04412917
p_int: 0.94377418
p_ni: 0.05622582
Data Source: BioPlex
CCL3L1
Tbio
Novelty: 0.01124082
p_int: 0.93965188
p_ni: 0.06034812
Data Source: BioPlex
Publication Statistics
PubMed Score  492.83

PubMed score by year
PubTator Score  509.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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