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Tbio
SNRPB
Small nuclear ribonucleoprotein-associated proteins B and B'

Protein Summary
Description
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:12975319). The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381342
  • ENSP00000370746
  • ENSG00000125835
  • ENST00000438552
  • ENSP00000412566

Symbol
  • COD
  • SNRPB1
  • COD
  • CCMS
  • SNRPB1
  • SmB/B'
  • Sm-B/B'
  • snRNP-B
  • SmB/SmB'
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
interacting protein
0.92
kinase perturbation
0.88
transcription factor binding site profile
0.82
protein complex
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.19   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.19   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Metabolism of non-coding RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Gene Ontology Terms (32)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (431)
1 – 10 of 431
SNRPN
Tbio
Novelty: 0.002157
p_int: 0.999999998
p_ni: 2e-9
Score: 0.9
Data Source: BioPlex,STRINGDB
CMTR2
Tbio
Family: Enzyme
Novelty: 0.11208282
p_int: 0.999999864
p_ni: 1.36e-7
Data Source: BioPlex
FARP1
Tbio
Novelty: 0.04040696
p_int: 0.999999848
p_ni: 1.51e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
RNPC3
Tbio
Novelty: 0.07154673
p_int: 0.999995605
p_ni: 0.000004394
Score: 0.967
Data Source: BioPlex,STRINGDB
CLNS1A
Tbio
Novelty: 0.01824362
p_int: 0.999988378
p_ni: 0.000011622
Score: 0.992
Data Source: BioPlex,STRINGDB
PAXBP1
Tbio
Novelty: 0.13631396
p_int: 0.999977239
p_ni: 0.000022761
Score: 0.157
Data Source: BioPlex,STRINGDB
DPP8
Tchem
Family: Enzyme
Novelty: 0.00678793
p_int: 0.999963474
p_ni: 0.000036526
Data Source: BioPlex
PDCD7
Tbio
Novelty: 0.15531712
p_int: 0.999945751
p_ni: 0.000054246
p_wrong: 3e-9
Score: 0.9
Data Source: BioPlex,STRINGDB
TFIP11
Tbio
Novelty: 0.01546496
p_int: 0.999929607
p_ni: 0.000070393
Score: 0.942
Data Source: BioPlex,STRINGDB
ZRSR2
Tbio
Novelty: 0.03449891
p_int: 0.999913179
p_ni: 0.000081195
p_wrong: 0.000005626
Score: 0.904
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  67.19

PubMed score by year
PubTator Score  161.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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