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Tchem
SLC2A4
Solute carrier family 2, facilitated glucose transporter member 4

Protein Summary
Description
Insulin-regulated facilitative glucose transporter. This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317370
  • ENSP00000320935
  • ENSG00000181856
  • ENST00000572485
  • ENSP00000461086

Symbol
  • GLUT4
  • GLUT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
chemical
0.89
histone modification site profile
0.88
protein domain
0.73
co-expressed gene
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2865.45   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 716   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2865.45   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 716   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (331)
SMAP2
Tbio
Novelty:  0.70006863
p_int:  0.99969888
p_ni:  0.000287792
p_wrong:  0.000013328
Score:  0.455
Data Source:  BioPlex,STRINGDB
DNAJC12
Tbio
Novelty:  0.05214775
p_int:  0.954027306
p_ni:  0.045945741
p_wrong:  0.000026953
Score:  0.347
Data Source:  BioPlex,STRINGDB
TBC1D4
Tbio
Novelty:  0.00549202
Score:  0.991
Data Source:  STRINGDB
LNPEP
Tchem
Family:  Enzyme
Novelty:  0.00249049
Score:  0.981
Data Source:  STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.978
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.973
Data Source:  STRINGDB
MYO1C
Tbio
Novelty:  0.00967011
Score:  0.971
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.969
Data Source:  STRINGDB
STX4
Tbio
Novelty:  0.00831588
Score:  0.967
Data Source:  STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
Score:  0.967
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (35)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
Developmental Biology
Reactome
Membrane Trafficking
Reactome
SLC-mediated transmembrane transport
Reactome
Transcriptional regulation of white adipocyte differentiation
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
Developmental Biology
Membrane Trafficking
SLC-mediated transmembrane transport
Transcriptional regulation of white adipocyte differentiation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
6
5
15.8
99.3
birth weight
4
3
4
89.4
apolipoprotein B measurement
2
4
4
89.4
myeloid white cell count
1
1
1
79.6
low density lipoprotein cholesterol measurement
3
3
4
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
5
15.8
99.3
birth weight
4
89.4
apolipoprotein B measurement
4
89.4
myeloid white cell count
1
79.6
low density lipoprotein cholesterol measurement
4
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 4
VGNC:9621
468443
Macaque
solute carrier family 2 member 4
714701
Mouse
MGI:95758
20528
Rat
RGD:2711
25139
Dog
solute carrier family 2 member 4
VGNC:53442
403673
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 4
Macaque
solute carrier family 2 member 4
Mouse
Rat
Dog
solute carrier family 2 member 4
Publication Statistics
PubMed Score 2865.45
PubMed score by year
PubTator Score 1321.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title