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Tbio
HOXB2
Homeobox protein Hox-B2

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330070
  • ENSP00000331741
  • ENSG00000173917

Symbol
  • HOX2H
  • K8
  • HOX2
  • HOX2H
  • Hox-2.8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.96
small molecule perturbation
0.82
protein domain
0.73
tissue sample
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.74   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.74   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox B2
VGNC:9325
749224
Mouse
MGI:96183
103889
Rat
RGD:2319509
100361765
Dog
homeobox B2
608880
Horse
homeobox B2 [Source:HGNC Symbol;Acc:HGNC:5113]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox B2
Mouse
Rat
Dog
homeobox B2
Horse
homeobox B2 [Source:HGNC Symbol;Acc:HGNC:5113]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P14652-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (74)
1 – 10 of 74
PKNOX1
Tbio
Family: TF
Novelty: 0.01063674
Score: 0.963
Data Source: STRINGDB
PBX1
Tbio
Family: TF
Novelty: 0.00329442
Score: 0.959
Data Source: STRINGDB
MEIS1
Tbio
Family: TF
Novelty: 0.00480433
Score: 0.952
Data Source: STRINGDB
EGR2
Tbio
Family: TF
Novelty: 0.00215433
Score: 0.95
Data Source: STRINGDB
HOXB1
Tbio
Family: TF
Novelty: 0.00731831
Score: 0.928
Data Source: STRINGDB
ASH2L
Tbio
Family: Enzyme
Novelty: 0.01586766
Score: 0.914
Data Source: STRINGDB
KMT2C
Tbio
Family: Epigenetic
Novelty: 0.00689437
Score: 0.913
Data Source: STRINGDB
KDM6A
Tchem
Family: Epigenetic
Novelty: 0.00267001
Score: 0.913
Data Source: STRINGDB
KMT2D
Tbio
Family: Epigenetic
Novelty: 0.00380525
Score: 0.913
Data Source: STRINGDB
POLR2I
Tbio
Family: Enzyme
Novelty: 0.03100605
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.74

PubMed score by year
PubTator Score  29.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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