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Tbio
MYL6B
Myosin light chain 6B

Protein Summary
Description
Regulatory light chain of myosin. Does not bind calcium. Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000550443
  • ENSP00000446643
  • ENSG00000196465
  • ENST00000553066
  • ENSP00000450385

Symbol
  • MLC1SA
  • MLC1SA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
histone modification site profile
0.85
interacting protein
0.85
transcription factor binding site profile
0.81
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
MYL6
Tbio
Novelty:  0.00594485
p_int:  0.892500274
p_ni:  0.107499727
Score:  0.937
Data Source:  BioPlex,STRINGDB
SPA17
Tbio
Novelty:  0.02632554
p_int:  0.824590436
p_ni:  0.175409564
Score:  0.544
Data Source:  BioPlex,STRINGDB
MYLK
Tchem
Family:  Kinase
Novelty:  0.00102277
Score:  0.992
Data Source:  STRINGDB
MYH11
Tbio
Novelty:  0.00142474
Score:  0.977
Data Source:  STRINGDB
TPM4
Tbio
Novelty:  0.00557194
Score:  0.961
Data Source:  STRINGDB
TPM2
Tbio
Novelty:  0.00406572
Score:  0.961
Data Source:  STRINGDB
TPM1
Tbio
Novelty:  0.00261206
Score:  0.959
Data Source:  STRINGDB
TPM3
Tbio
Novelty:  0.00108151
Score:  0.959
Data Source:  STRINGDB
MYH13
Tbio
Novelty:  0.01077846
Score:  0.956
Data Source:  STRINGDB
MYH10
Tchem
Novelty:  0.00624251
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 5 of 5
Pathways (6)
Muscle contraction (R-HSA-397014)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
5
5
97.2
3
2
0
1.3
89.2
3
3
0
1.1
88.5
mathematical ability
2
2
2
82.9
body mass index
3
2
3
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
97.2
0
1.3
89.2
0
1.1
88.5
mathematical ability
2
82.9
body mass index
3
75
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
myosin light chain 6B
106992272
Mouse
MGI:1917789
216459
Dog
myosin light chain 6B
VGNC:43546
606992
Horse
myosin light chain 6B
VGNC:20487
100059367
Cow
myosin light chain 6B
VGNC:31803
515421
Species
Name
OMA
EggNOG
Inparanoid
Macaque
myosin light chain 6B
Mouse
Dog
myosin light chain 6B
Horse
myosin light chain 6B
Cow
myosin light chain 6B
Publication Statistics
PubMed Score 67.45
PubMed score by year
PubTator Score 2.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title