Tchem CCNB1 G2/mitotic-specific cyclin-B1

Protein Summary

Description

Essential for the control of the cell cycle at the G2/M (mitosis) transition. The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P14635
• A8K066
• Q5TZP9

Gene Name

• CCNB1

Ensembl ID

• ENST00000256442
• ENSP00000256442
• ENSG00000134057
• ENST00000505500
• ENSP00000424588

Symbol

• CCNB
• CCNB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	1
transcription factor perturbation	0.99
interacting protein	0.96
virus perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G2/mitotic-specific Cyclin-b1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G2/mitotic-specific Cyclin-b1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1742.44   (req: < 5)

Gene RIFs: 251   (req: <= 3)

Antibodies: 1709   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1742.44   (req: >= 5)

Gene RIFs: 251   (req: > 3)

Antibodies: 1709   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0