Protein Summary
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
- ENST00000299767
- ENSP00000299767
- ENSG00000166598
- GRP94
- TRA1
- ECGP
- GP96
- TRA1
- GRP94
- HEL35
- HEL-S-125m
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 0.98 | ||
molecular function | 0.97 | ||
virus perturbation | 0.94 | ||
biological process | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.66 (req: < 5)
Gene RIFs: 145 (req: <= 3)
Antibodies: 1239 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.66 (req: >= 5)
Gene RIFs: 145 (req: > 3)
Antibodies: 1239 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 112
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0