Tchem HSP90B1 Endoplasmin

Protein Classes

PANTHER Classes

Protein / Chaperone / Hsp90 Family Chaperone / Endoplasmin

DTO Classes

Protein / Chaperone / Hsp90 Family Chaperone / Endoplasmin

Protein Summary

Description

Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P14625
• Q96A97

Gene Name

• HSP90B1

Ensembl ID

• ENST00000299767
• ENSP00000299767
• ENSG00000166598

Symbol

• GRP94
• TRA1
• ECGP
• GP96
• TRA1
• GRP94
• HEL35
• HEL-S-125m

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor perturbation	0.98
molecular function	0.97
virus perturbation	0.94
biological process	0.93

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 656.4   (req: < 5)

Gene RIFs: 116   (req: <= 3)

Antibodies: 1239   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 656.4   (req: >= 5)

Gene RIFs: 116   (req: > 3)

Antibodies: 1239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 59

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (59)

Explore Active Ligands

1 – 10 of 59

CHEMBL252164

HSP90B1Tchem

Ki: 8.4

CHEMBL467399

HSP90B1Tchem

Ki: 6.75

CHEMBL200102

HSP90B1Tchem

IC50: 7.58

CHEMBL560895

HSP90B1Tchem

Ki: 6.32

CHEMBL1230584

HSP90B1Tchem

Ki: 7.21

CHEMBL3104858

HSP90B1Tchem

Ki: 6.43

CHEMBL3235342

HSP90B1Tchem

Ki: 6.21

CHEMBL3104859

HSP90B1Tchem

Ki: 8.3

CHEMBL3235344

HSP90B1Tchem

Ki: 6.08

CHEMBL3235335

HSP90B1Tchem

Ki: 6.24

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (32)

Reactome (17)

KEGG (8)

PathwayCommons (2)

WikiPathways (5)

ATF6 (ATF6-alpha) activates chaperone genes (R-HSA-381183)

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Items per page:

5

1 – 5 of 17

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ATF6 (ATF6-alpha) activates chaperone genes	11 targets	R-HSA-381183
Reactome	ATF6 (ATF6-alpha) activates chaperones	13 targets	R-HSA-381033
Reactome	Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
ATF6 (ATF6-alpha) activates chaperone genes	11 targets	R-HSA-381183
ATF6 (ATF6-alpha) activates chaperones	13 targets	R-HSA-381033
Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (40)

Functions (6)

Components (17)

Processes (17)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
low-density lipoprotein particle receptor binding	Inferred from Direct Assay (IDA)	MGI
protein phosphatase binding	Inferred from Direct Assay (IDA)	MGI
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
calcium ion binding	Traceable Author Statement (TAS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
unfolded protein binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (420)

Explore Interacting Targets

1 – 10 of 420

• See Interactions on String-DB

OS9

Tbio

Novelty: 0.01598375

p_int: 0.96153235

p_ni: 0.03846765

Score: 0.969

Data Source: BioPlex,STRINGDB

LYZL2

Tdark

Family: Enzyme

Novelty: 1.38461538

p_int: 0.757309725

p_ni: 0.242690275

Score: 0.239

Data Source: BioPlex,STRINGDB

HSPA5

Tchem

Novelty: 0.00051387

Score: 0.999

Data Source: STRINGDB

CALR

Tbio

Novelty: 0.00058349

Score: 0.999

Data Source: STRINGDB

P4HB

Tbio

Family: Enzyme

Novelty: 0.00117072

Score: 0.998

Data Source: STRINGDB

PDIA6

Tchem

Family: Enzyme

Novelty: 0.02339159

Score: 0.997

Data Source: STRINGDB

DNAJC3

Tbio

Novelty: 0.03555633

Score: 0.995

Data Source: STRINGDB

HYOU1

Tbio

Novelty: 0.00973194

Score: 0.995

Data Source: STRINGDB

PRKCSH

Tbio

Family: Enzyme

Novelty: 0.00609928

Score: 0.994

Data Source: STRINGDB

PDIA4

Tbio

Family: Enzyme

Novelty: 0.0202442

Score: 0.991

Data Source: STRINGDB

Publication Statistics

PubMed Score  656.40

PubMed score by year

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PubTator Score  415.91

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELR

1-70

EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDK

70-140

EKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVI

140-210

VTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIY

210-280

VWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEV

280-350

EEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD

350-420

DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGT

420-490

NIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLK

490-560

KGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK

560-630

IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRR

630-700

IKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDT

700-770

TEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL

770-803

MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL

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Uniprot Keyword

3D-structure
Acetylation
ATP-binding
Calcium
Chaperone
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein