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Tchem
HSP90B1
Endoplasmin

Protein Summary
Description
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299767
  • ENSP00000299767
  • ENSG00000166598

Symbol
  • GRP94
  • TRA1
  • ECGP
  • GP96
  • TRA1
  • GRP94
  • HEL35
  • HEL-S-125m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.98
molecular function
0.97
virus perturbation
0.94
biological process
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.66   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 1239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.66   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 1239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 112
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0