Protein Classes
Protein Summary
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
- ENST00000299767
- ENSP00000299767
- ENSG00000166598
- GRP94
- TRA1
- ECGP
- GP96
- TRA1
- GRP94
- HEL35
- HEL-S-125m
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 0.98 | ||
molecular function | 0.97 | ||
virus perturbation | 0.94 | ||
biological process | 0.93 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 782.7 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 1239 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 782.7 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 1239 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 59
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (59)
1 – 10 of 59
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | heat shock protein 90 beta family member 1 | VGNC:5423 | 452187 | |||||
Macaque | heat shock protein 90 beta family member 1 | 699568 | ||||||
Mouse | MGI:98817 | 22027 | ||||||
Rat | RGD:1310482 | 362862 | ||||||
Dog | heat shock protein 90 beta family member 1 | VGNC:54212 | 404019 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | heat shock protein 90 beta family member 1 | |||||
Macaque | heat shock protein 90 beta family member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | heat shock protein 90 beta family member 1 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (32)
Reactome (17)
KEGG (8)
PathwayCommons (2)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 17
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ATF6 (ATF6-alpha) activates chaperone genes | ||||
Reactome | ATF6 (ATF6-alpha) activates chaperones | ||||
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ATF6 (ATF6-alpha) activates chaperone genes | ||||
ATF6 (ATF6-alpha) activates chaperones | ||||
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Gene Ontology Terms (40)
Functions (6)
Components (17)
Processes (17)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (420)
1 – 10 of 420
OS9
Novelty: 0.01490339
p_int: 0.96153235
p_ni: 0.03846765
Score: 0.969
Data Source: BioPlex,STRINGDB
LYZL2
Family: Enzyme
Novelty: 0.50542161
p_int: 0.757309725
p_ni: 0.242690275
Score: 0.239
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00043424
Score: 0.999
Data Source: STRINGDB
CALR
Novelty: 0.0004479
Score: 0.999
Data Source: STRINGDB
P4HB
Family: Enzyme
Novelty: 0.00107905
Score: 0.998
Data Source: STRINGDB
PDIA6
Family: Enzyme
Novelty: 0.01692178
Score: 0.997
Data Source: STRINGDB
DNAJC3
Novelty: 0.02129782
Score: 0.995
Data Source: STRINGDB
HYOU1
Novelty: 0.00833649
Score: 0.995
Data Source: STRINGDB
PRKCSH
Family: Enzyme
Novelty: 0.00787916
Score: 0.994
Data Source: STRINGDB
PDIA4
Family: Enzyme
Novelty: 0.01412168
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score 782.70
PubMed score by year
PubTator Score 415.91
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword