Protein Classes
Protein Summary
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
- ENST00000299767
- ENSP00000299767
- ENSG00000166598
- GRP94
- TRA1
- ECGP
- GP96
- TRA1
- GRP94
- HEL35
- HEL-S-125m
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 0.98 | ||
molecular function | 0.97 | ||
virus perturbation | 0.94 | ||
biological process | 0.93 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 656.4 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 1239 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 656.4 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 1239 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 59
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (59)
1 – 10 of 59
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (32)
Reactome (17)
KEGG (8)
PathwayCommons (2)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 17
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ATF6 (ATF6-alpha) activates chaperone genes | ||||
Reactome | ATF6 (ATF6-alpha) activates chaperones | ||||
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ATF6 (ATF6-alpha) activates chaperone genes | ||||
ATF6 (ATF6-alpha) activates chaperones | ||||
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Gene Ontology Terms (40)
Functions (6)
Components (17)
Processes (17)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (420)
1 – 10 of 420
OS9
Novelty: 0.01598375
p_int: 0.96153235
p_ni: 0.03846765
Score: 0.969
Data Source: BioPlex,STRINGDB
LYZL2
Family: Enzyme
Novelty: 1.38461538
p_int: 0.757309725
p_ni: 0.242690275
Score: 0.239
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00051387
Score: 0.999
Data Source: STRINGDB
CALR
Novelty: 0.00058349
Score: 0.999
Data Source: STRINGDB
P4HB
Family: Enzyme
Novelty: 0.00117072
Score: 0.998
Data Source: STRINGDB
PDIA6
Family: Enzyme
Novelty: 0.02339159
Score: 0.997
Data Source: STRINGDB
DNAJC3
Novelty: 0.03555633
Score: 0.995
Data Source: STRINGDB
HYOU1
Novelty: 0.00973194
Score: 0.995
Data Source: STRINGDB
PRKCSH
Family: Enzyme
Novelty: 0.00609928
Score: 0.994
Data Source: STRINGDB
PDIA4
Family: Enzyme
Novelty: 0.0202442
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score 656.40
PubMed score by year
PubTator Score 415.91
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELR
1-70
EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDK
70-140
EKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVI
140-210
VTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIY
210-280
VWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEV
280-350
EEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
350-420
DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGT
420-490
NIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLK
490-560
KGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDK
560-630
IEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRR
630-700
IKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDT
700-770
TEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
770-803
MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
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