Protein Summary
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
- ENST00000299767
- ENSP00000299767
- ENSG00000166598
- GRP94
- TRA1
- ECGP
- GP96
- TRA1
- GRP94
- HEL35
- HEL-S-125m
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 0.98 | ||
molecular function | 0.97 | ||
virus perturbation | 0.94 | ||
biological process | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 799.41 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 1239 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 799.41 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 1239 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 73
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (73)
Protein-Protein Interactions (420)
OS9
Novelty: 0.01490339
p_int: 0.96153235
p_ni: 0.03846765
Score: 0.969
Data Source: BioPlex,STRINGDB
LYZL2
Family: Enzyme
Novelty: 0.50542161
p_int: 0.757309725
p_ni: 0.242690275
Score: 0.239
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (32)
Reactome (17)
KEGG (8)
PathwayCommons (2)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ATF6 (ATF6-alpha) activates chaperone genes | ||||
Reactome | ATF6 (ATF6-alpha) activates chaperones | ||||
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ATF6 (ATF6-alpha) activates chaperone genes | ||||
ATF6 (ATF6-alpha) activates chaperones | ||||
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (6)
Components (17)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
central corneal thickness | 2 | 2 | 0 | 3.2 | 88.3 | ||||
intraocular pressure measurement | 1 | 2 | 2 | 69.1 | |||||
heel bone mineral density | 2 | 2 | 2 | 65.7 | |||||
corneal topography | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
central corneal thickness | 0 | 3.2 | 88.3 | ||||
intraocular pressure measurement | 2 | 69.1 | |||||
heel bone mineral density | 2 | 65.7 | |||||
corneal topography | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | heat shock protein 90 beta family member 1 | VGNC:5423 | 452187 | |||||
Macaque | heat shock protein 90 beta family member 1 | 699568 | ||||||
Mouse | MGI:98817 | 22027 | ||||||
Rat | RGD:1310482 | 362862 | ||||||
Dog | heat shock protein 90 beta family member 1 | VGNC:54212 | 404019 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | heat shock protein 90 beta family member 1 | |||||
Macaque | heat shock protein 90 beta family member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | heat shock protein 90 beta family member 1 | |||||
Publication Statistics
PubMed Score 799.41
PubMed score by year
PubTator Score 415.91
PubTator score by year
Related Publications
Text Mined References (173)
GeneRif Annotations (116)
Items per page:
0 of 0
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