Tbio ACYP2 Acylphosphatase-2

Protein Summary

Description

Its physiological role is not yet clear. Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P14621

Gene Name

• ACYP2

Ensembl ID

• ENST00000394666
• ENSP00000378161
• ENSG00000170634

Symbol

• ACYP
• ACYM
• ACYP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor binding site profile	0.89
histone modification site profile	0.88
disease perturbation	0.83
PubMedID	0.63

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Acylphosphatase-2

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Acylphosphatase-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.1   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.1   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (35)

Explore Interacting Targets

1 – 10 of 35

• See Interactions on String-DB

CARM1

Tchem

Family:  Epigenetic

Novelty:  0.00623937

p_int:  0.99506227

p_ni:  0.00493773

Data Source:  BioPlex

OGA

Tchem

Family:  Enzyme

Novelty:  0.00035723

p_int:  0.992156295

p_ni:  0.007843704

Data Source:  BioPlex

BCS1L

Tbio

Family:  Enzyme

Novelty:  0.01764582

p_int:  0.989035304

p_ni:  0.010963567

p_wrong:  0.000001129

Data Source:  BioPlex

GFPT2

Tbio

Family:  Enzyme

Novelty:  0.01049877

p_int:  0.875189787

p_ni:  0.124810213

Data Source:  BioPlex

ACSS2

Tchem

Family:  Enzyme

Novelty:  0.00448879

Score:  0.913

Data Source:  STRINGDB

ACOT12

Tbio

Family:  Enzyme

Novelty:  0.04464523

Score:  0.9

Data Source:  STRINGDB

ACSS1

Tbio

Family:  Enzyme

Novelty:  0.02003886

Score:  0.9

Data Source:  STRINGDB

ACYP1

Tbio

Family:  Enzyme

Novelty:  0.15208554

Score:  0.808

Data Source:  STRINGDB

TSPYL6

Tdark

Novelty:  0.68478376

Score:  0.79

Data Source:  STRINGDB

ZNF208

Tdark

Family:  TF

Novelty:  0.14316544

Score:  0.79

Data Source:  STRINGDB

Nearest Tclin Targets (1)

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Upstream (1)

1 – 1 of 1

ALDH2

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Pyruvate metabolism

2: Metabolic pathways

Pathways (3)

KEGG (2)

PathwayCommons (1)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Pyruvate metabolism	39 targets	path:hsa00620
KEGG	Metabolic pathways	1433 targets	path:hsa01100

Name	Explore in Pharos	Explore in Source
Pyruvate metabolism	39 targets	path:hsa00620
Metabolic pathways	1433 targets	path:hsa01100

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (2)

Processes (1)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
acylphosphatase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (9)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	7	7		93.4
glomerular filtration rate	EFO_0005208	2	2	1	6.2	60.8
body mass index	EFO_0004340	1	1	1		52.7
telomere length	EFO_0004505	2	2	2		52.3
smoking status measurement	EFO_0006527	1	1	1		27.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	7		93.4
glomerular filtration rate	EFO_0005208	1	6.2	60.8
body mass index	EFO_0004340	1		52.7
telomere length	EFO_0004505	2		52.3
smoking status measurement	EFO_0006527	1		27.3

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
Direct protein sequencing
Hydrolase
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
body mass index
circadian rhythm
cortical surface area measurement
glomerular filtration rate
grip strength measurement
heel bone mineral density
smoking status measurement
sudden cardiac arrest
telomere length

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	acylphosphatase 2, muscle type	MGI:1922822	75572
Rat	acylphosphatase 2	RGD:1595836	364224
Dog	acylphosphatase 2	VGNC:37567	474595
Horse	acylphosphatase 2	VGNC:15042	100630291
Cow	acylphosphatase 2	VGNC:25599	767889

Species	Name	OMA	EggNOG	Inparanoid
Mouse	acylphosphatase 2, muscle type
Rat	acylphosphatase 2
Dog	acylphosphatase 2
Horse	acylphosphatase 2
Cow	acylphosphatase 2

Publication Statistics

PubMed Score 43.10

PubMed score by year

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PubTator Score 17.95

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (22)

Items per page:

10

0 of 0

PMID	Year	Title