Protein Summary
Its physiological role is not yet clear. Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
- ENST00000394666
- ENSP00000378161
- ENSG00000170634
- ACYP
- ACYM
- ACYP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
transcription factor binding site profile | 0.89 | ||
histone modification site profile | 0.88 | ||
disease perturbation | 0.83 | ||
PubMedID | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.1 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 97 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.1 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 97 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (35)
CARM1
Family: Epigenetic
Novelty: 0.00623937
p_int: 0.99506227
p_ni: 0.00493773
Data Source: BioPlex
OGA
Family: Enzyme
Novelty: 0.00035723
p_int: 0.992156295
p_ni: 0.007843704
Data Source: BioPlex
BCS1L
Family: Enzyme
Novelty: 0.01764582
p_int: 0.989035304
p_ni: 0.010963567
p_wrong: 0.000001129
Data Source: BioPlex
GFPT2
Family: Enzyme
Novelty: 0.01049877
p_int: 0.875189787
p_ni: 0.124810213
Data Source: BioPlex
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (3)
KEGG (2)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Pyruvate metabolism | ||||
KEGG | Metabolic pathways | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Pyruvate metabolism | ||||
Metabolic pathways | ||||
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 7 | 7 | 93.4 | |||||
glomerular filtration rate | 2 | 2 | 1 | 6.2 | 60.8 | ||||
body mass index | 1 | 1 | 1 | 52.7 | |||||
telomere length | 2 | 2 | 2 | 52.3 | |||||
smoking status measurement | 1 | 1 | 1 | 27.3 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 7 | 93.4 | |||||
glomerular filtration rate | 1 | 6.2 | 60.8 | ||||
body mass index | 1 | 52.7 | |||||
telomere length | 2 | 52.3 | |||||
smoking status measurement | 1 | 27.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1922822 | 75572 | ||||||
Rat | RGD:1595836 | 364224 | ||||||
Dog | acylphosphatase 2 | VGNC:37567 | 474595 | |||||
Horse | acylphosphatase 2 | VGNC:15042 | 100630291 | |||||
Cow | acylphosphatase 2 | VGNC:25599 | 767889 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | acylphosphatase 2 | |||||
Horse | acylphosphatase 2 | |||||
Cow | acylphosphatase 2 | |||||
Publication Statistics
PubMed Score 43.10
PubMed score by year
PubTator Score 17.95
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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