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Tchem
PKM
Pyruvate kinase PKM

Protein Summary
Description
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319622
  • ENSP00000320171
  • ENSG00000067225
  • ENST00000335181
  • ENSP00000334983
  • ENST00000449901
  • ENSP00000403365
  • ENST00000565154
  • ENSP00000455901
  • ENST00000565184
  • ENSP00000455736
  • ENST00000568459
  • ENSP00000456970

Symbol
  • OIP3
  • PK2
  • PK3
  • PKM2
  • PK3
  • TCB
  • OIP3
  • PKM2
  • CTHBP
  • THBP1
  • HEL-S-30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
viral protein
1
virus
1
molecular function
0.99
protein complex
0.98


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1463.15   (req: < 5)
Gene RIFs: 281   (req: <= 3)
Antibodies: 1066   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1463.15   (req: >= 5)
Gene RIFs: 281   (req: > 3)
Antibodies: 1066   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate kinase M1/2
VGNC:49018
748700
Macaque
pyruvate kinase M1/2
697742
Mouse
MGI:97591
18746
Rat
RGD:3337
25630
Dog
pyruvate kinase M1/2
403874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate kinase M1/2
Macaque
pyruvate kinase M1/2
Mouse
Rat
Dog
pyruvate kinase M1/2
Protein Data Bank (32)
1 – 5 of 32
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (32)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Immune System
Innate Immune System
Metabolism
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (496)
1 – 10 of 496
GREM2
Tbio
Novelty: 0.01839564
p_int: 0.874895559
p_ni: 0.125104441
Data Source: BioPlex
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.874627622
p_ni: 0.125372378
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.767213419
p_ni: 0.232786581
Score: 0.364
Data Source: BioPlex,STRINGDB
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.766843414
p_ni: 0.233156586
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.765904555
p_ni: 0.234095445
Score: 0.19
Data Source: BioPlex,STRINGDB
PAPLN
Tbio
Novelty: 0.06871524
p_int: 0.756537652
p_ni: 0.243462348
Score: 0.19
Data Source: BioPlex,STRINGDB
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.752493335
p_ni: 0.247506665
Data Source: BioPlex
ENO1
Tchem
Family: Enzyme
Novelty: 0.00109178
Score: 0.993
Data Source: STRINGDB
ENO3
Tbio
Family: Enzyme
Novelty: 0.00322051
Score: 0.989
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.987
Data Source: STRINGDB
Publication Statistics
PubMed Score  1463.15

PubMed score by year
PubTator Score  558.71

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer