You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
INSRR
Insulin receptor-related protein

Protein Summary
Description
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368195
  • ENSP00000357178
  • ENSG00000027644

Symbol
  • IRR
  • IRR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
gene perturbation
0.57
tissue
0.53
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.02   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.02   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (76)
1 – 10 of 76
INSR
Tclin
Family: Kinase
Novelty: 0.00230617
Score: 0.974
Data Source: STRINGDB
PTPN1
Tchem
Family: Enzyme
Novelty: 0.00065779
Score: 0.962
Data Source: STRINGDB
IGF1R
Tclin
Family: Kinase
Novelty: 0.00034532
Score: 0.961
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.94
Data Source: STRINGDB
IGF1
Tbio
Novelty: 0.00003878
Score: 0.937
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.862
Data Source: STRINGDB
PTPN2
Tchem
Family: Enzyme
Novelty: 0.00372891
Score: 0.796
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.764
Data Source: STRINGDB
PTPRR
Tbio
Family: Enzyme
Novelty: 0.02065754
Score: 0.762
Data Source: STRINGDB
PTPN22
Tchem
Family: Enzyme
Novelty: 0.00168847
Score: 0.76
Data Source: STRINGDB
Publication Statistics
PubMed Score  166.02

PubMed score by year
PubTator Score  1106.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer