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Tbio
NCF1
Neutrophil cytosol factor 1

Protein Summary
Description
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
1
chemical
0.97
hub protein
0.97
biological process
0.85
biological term
0.78


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 834.99   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 850   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 834.99   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 850   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neutrophil cytosolic factor 1
694207
Mouse
MGI:97283
17969
Rat
RGD:61307
114553
Dog
neutrophil cytosolic factor 1
VGNC:54048
607700
Cow
neutrophil cytosolic factor 1
281345
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neutrophil cytosolic factor 1
Mouse
Rat
Dog
neutrophil cytosolic factor 1
Cow
neutrophil cytosolic factor 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14598-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Cellular responses to external stimuli
Cellular responses to stress
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (225)
1 – 10 of 225
NCF2
Tbio
Novelty: 0.00274685
Score: 0.999
Data Source: Reactome,STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.998
Data Source: Reactome,STRINGDB
CYBA
Tbio
Novelty: 0.00177762
Score: 0.997
Data Source: Reactome,STRINGDB
NOXA1
Tbio
Family: Enzyme
Novelty: 0.03052419
Score: 0.991
Data Source: Reactome,STRINGDB
NOX1
Tchem
Family: Enzyme
Novelty: 0.0016839
Score: 0.986
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.984
Data Source: Reactome,STRINGDB
NOX3
Tbio
Family: Enzyme
Novelty: 0.01350666
Score: 0.978
Data Source: Reactome,STRINGDB
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
Score: 0.976
Data Source: STRINGDB
NCF4
Tbio
Novelty: 0.00560244
Score: 0.972
Data Source: Reactome,STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.969
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  834.99

PubMed score by year
PubTator Score  401.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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