Tchem PLA2G2A Phospholipase A2, membrane associated

Protein Summary

Description

Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P14555
• A8K5I7
• Q6DN24
• Q6IBD9
• Q9UCD2

Gene Name

• PLA2G2A

Ensembl ID

• ENST00000375111
• ENSP00000364252
• ENSG00000188257
• ENST00000400520
• ENSP00000383364

Symbol

• PLA2B
• PLA2L
• RASF-A
• MOM1
• PLA2
• PLA2B
• PLA2L
• PLA2S
• PLAS1
• sPLA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.92
biological process	0.87
disease	0.84
metabolite	0.8
small molecule perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Hydrolase / Lipase / Phospholipase / Phospholipase A2, Membrane Associated

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Phospholipase A2, Membrane Associated

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1264   (req: < 5)

Gene RIFs: 175   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1264   (req: >= 5)

Gene RIFs: 175   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 207

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0