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Tchem
PLA2G2A
Phospholipase A2, membrane associated

Protein Summary
Description
Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375111
  • ENSP00000364252
  • ENSG00000188257
  • ENST00000400520
  • ENSP00000383364

Symbol
  • PLA2B
  • PLA2L
  • RASF-A
  • MOM1
  • PLA2
  • PLA2B
  • PLA2L
  • PLA2S
  • PLAS1
  • sPLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.92
biological process
0.87
disease
0.84
metabolite
0.8
small molecule perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1126.75   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1126.75   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 207
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (207)
varespladib
Rendered image for varespladib
CHEMBL515637
Rendered image for CHEMBL515637
CHEMBL148649
Rendered image for CHEMBL148649
CHEMBL446349
Rendered image for CHEMBL446349
CHEMBL514692
Rendered image for CHEMBL514692
CHEMBL208315
Rendered image for CHEMBL208315
CHEMBL332993
Rendered image for CHEMBL332993
CHEMBL514841
Rendered image for CHEMBL514841
CHEMBL346196
Rendered image for CHEMBL346196
CHEMBL208429
Rendered image for CHEMBL208429
Protein-Protein Interactions (116)
GPC1
Tbio
Novelty:  0.00293087
Score:  0.917
Data Source:  STRINGDB
PLA2G7
Tchem
Family:  Enzyme
Novelty:  0.00270949
Score:  0.879
Data Source:  STRINGDB
PLA2G6
Tchem
Family:  Enzyme
Novelty:  0.00262569
Score:  0.876
Data Source:  STRINGDB
PLA2R1
Tbio
Family:  Enzyme
Novelty:  0.00355963
Score:  0.869
Data Source:  STRINGDB
ALOX12
Tchem
Family:  Enzyme
Novelty:  0.00287761
Score:  0.856
Data Source:  STRINGDB
PLA2G16
Tchem
Novelty:  0.02310886
Score:  0.851
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.851
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.839
Data Source:  STRINGDB
ALOX15
Tchem
Family:  Enzyme
Novelty:  0.00184734
Score:  0.838
Data Source:  STRINGDB
PLA2G15
Tbio
Family:  Enzyme
Novelty:  0.01546393
Score:  0.835
Data Source:  STRINGDB
Pathways (31)
Acyl chain remodelling of PC (R-HSA-1482788)

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Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
74.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
74.3
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IIA
VGNC:9878
456587
Macaque
phospholipase A2 group IIA
704520
Rat
RGD:620857
29692
Horse
phospholipase A2 group IIA
VGNC:21508
100037401
Cow
phospholipase A2, group IIA (platelets, synovial fluid)
507201
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IIA
Macaque
phospholipase A2 group IIA
Rat
Horse
phospholipase A2 group IIA
Cow
phospholipase A2, group IIA (platelets, synovial fluid)
Publication Statistics
PubMed Score 1126.75
PubMed score by year
PubTator Score 896.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title