PLA2G2A
Phospholipase A2, membrane associated
Protein Summary
Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA ...more
- ENST00000375111
- ENSP00000364252
- ENSG00000188257
- ENST00000400520
- ENSP00000383364
- PLA2B
- PLA2L
- RASF-A
- MOM1
- PLA2
- PLA2B
- PLA2L
- PLA2S
- PLAS1
- sPLA2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.92 | ||
biological process | 0.87 | ||
disease | 0.84 | ||
metabolite | 0.8 | ||
small molecule perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1126.75 (req: < 5)
Gene RIFs: 150 (req: <= 3)
Antibodies: 232 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1126.75 (req: >= 5)
Gene RIFs: 150 (req: > 3)
Antibodies: 232 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 207
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (207)
Protein-Protein Interactions (116)
Nearest Tclin Targets (4)
Upstream (1)
Downstream (3)
1 – 1 of 1
Pathways (31)
Reactome (13)
KEGG (10)
PathwayCommons (2)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acyl chain remodelling of PC | ||||
Reactome | Acyl chain remodelling of PE | ||||
Reactome | Acyl chain remodelling of PG | ||||
Reactome | Acyl chain remodelling of PI | ||||
Reactome | Acyl chain remodelling of PS | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acyl chain remodelling of PC | ||||
Acyl chain remodelling of PE | ||||
Acyl chain remodelling of PG | ||||
Acyl chain remodelling of PI | ||||
Acyl chain remodelling of PS | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (6)
Components (8)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.4 | 74.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.4 | 74.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase A2 group IIA | VGNC:9878 | 456587 | |||||
Macaque | phospholipase A2 group IIA | 704520 | ||||||
Rat | RGD:620857 | 29692 | ||||||
Horse | phospholipase A2 group IIA | VGNC:21508 | 100037401 | |||||
Cow | phospholipase A2, group IIA (platelets, synovial fluid) | 507201 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase A2 group IIA | |||||
Macaque | phospholipase A2 group IIA | |||||
Rat | ||||||
Horse | phospholipase A2 group IIA | |||||
Cow | phospholipase A2, group IIA (platelets, synovial fluid) | |||||
Publication Statistics
PubMed Score 1126.75
PubMed score by year
PubTator Score 896.95
PubTator score by year
Related Publications
Text Mined References (197)
GeneRif Annotations (150)
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0 of 0
PMID | Year | Title |
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