Tchem PLA2G2A Phospholipase A2, membrane associated

Protein Summary

Description

Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P14555
• A8K5I7
• Q6DN24
• Q6IBD9
• Q9UCD2

Gene Name

• PLA2G2A

Ensembl ID

• ENST00000375111
• ENSP00000364252
• ENSG00000188257
• ENST00000400520
• ENSP00000383364

Symbol

• PLA2B
• PLA2L
• RASF-A
• MOM1
• PLA2
• PLA2B
• PLA2L
• PLA2S
• PLAS1
• sPLA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.92
biological process	0.87
disease	0.84
metabolite	0.8
small molecule perturbation	0.71

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1126.75   (req: < 5)

Gene RIFs: 150   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1126.75   (req: >= 5)

Gene RIFs: 150   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 207

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Active Ligands (207)

Explore Active Ligands

1 – 10 of 207

varespladib

PLA2G2ATchem Enzyme

pIC50 : 8.15

CHEMBL515637

PLA2G2ATchem Enzyme

pIC50 : 7.4

CHEMBL148649

PLA2G2ATchem Enzyme

pIC50 : 7.96

CHEMBL446349

PLA2G2ATchem Enzyme

pIC50 : 7

CHEMBL514692

PLA2G2ATchem Enzyme

pIC50 : 6.6

CHEMBL208315

PLA2G2ATchem Enzyme

pIC50 : 6.9

CHEMBL332993

PLA2G2ATchem Enzyme

pIC50 : 7.22

CHEMBL514841

PLA2G2ATchem Enzyme

pIC50 : 7.85

CHEMBL346196

PLA2G2ATchem Enzyme

pIC50 : 7.96

CHEMBL208429

PLA2G2ATchem Enzyme

pIC50 : 6.52

Protein-Protein Interactions (116)

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1 – 10 of 116

• See Interactions on String-DB

GPC1

Tbio

Novelty:  0.00293087

Score:  0.917

Data Source:  STRINGDB

PLA2G7

Tchem

Family:  Enzyme

Novelty:  0.00270949

Score:  0.879

Data Source:  STRINGDB

PLA2G6

Tchem

Family:  Enzyme

Novelty:  0.00262569

Score:  0.876

Data Source:  STRINGDB

PLA2R1

Tbio

Family:  Enzyme

Novelty:  0.00355963

Score:  0.869

Data Source:  STRINGDB

ALOX12

Tchem

Family:  Enzyme

Novelty:  0.00287761

Score:  0.856

Data Source:  STRINGDB

PLA2G16

Tchem

Novelty:  0.02310886

Score:  0.851

Data Source:  STRINGDB

PTGS2

Tclin

Family:  Enzyme

Novelty:  0.00007089

Score:  0.851

Data Source:  STRINGDB

ALOX5

Tclin

Family:  Enzyme

Novelty:  0.00062988

Score:  0.839

Data Source:  STRINGDB

ALOX15

Tchem

Family:  Enzyme

Novelty:  0.00184734

Score:  0.838

Data Source:  STRINGDB

PLA2G15

Tbio

Family:  Enzyme

Novelty:  0.01546393

Score:  0.835

Data Source:  STRINGDB

Pathways (31)

Reactome (13)

KEGG (10)

PathwayCommons (2)

WikiPathways (6)

Acyl chain remodelling of PC (R-HSA-1482788)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Acyl chain remodelling of PC	27 targets	R-HSA-1482788
Reactome	Acyl chain remodelling of PE	29 targets	R-HSA-1482839
Reactome	Acyl chain remodelling of PG	18 targets	R-HSA-1482925
Reactome	Acyl chain remodelling of PI	17 targets	R-HSA-1482922
Reactome	Acyl chain remodelling of PS	22 targets	R-HSA-1482801

Name	Explore in Pharos	Explore in Source
Acyl chain remodelling of PC	27 targets	R-HSA-1482788
Acyl chain remodelling of PE	29 targets	R-HSA-1482839
Acyl chain remodelling of PG	18 targets	R-HSA-1482925
Acyl chain remodelling of PI	17 targets	R-HSA-1482922
Acyl chain remodelling of PS	22 targets	R-HSA-1482801

Gene Ontology Terms (30)

Functions (6)

Components (8)

Processes (16)

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1 – 6 of 6

GO Term	Evidence	Assigned by
phospholipase A2 activity	Inferred from Direct Assay (IDA)	BHF-UCL
phospholipid binding	Inferred from Direct Assay (IDA)	BHF-UCL
calcium ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium-dependent phospholipase A2 activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ulcerative colitis	EFO_0000729	1	1	0	1.4	74.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ulcerative colitis	EFO_0000729	0	1.4	74.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Calcium
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Hydrolase
Lipid degradation
Lipid metabolism
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
ulcerative colitis

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	phospholipase A2 group IIA	VGNC:9878	456587
Macaque	phospholipase A2 group IIA		704520
Rat	phospholipase A2 group IIA	RGD:620857	29692
Horse	phospholipase A2 group IIA	VGNC:21508	100037401
Cow	phospholipase A2, group IIA (platelets, synovial fluid)		507201

Species	Name	OMA	EggNOG	Inparanoid
Chimp	phospholipase A2 group IIA
Macaque	phospholipase A2 group IIA
Rat	phospholipase A2 group IIA
Horse	phospholipase A2 group IIA
Cow	phospholipase A2, group IIA (platelets, synovial fluid)

Publication Statistics

PubMed Score 1126.75

PubMed score by year

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PubTator Score 896.95

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