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Tchem
AKR1A1
Alcohol dehydrogenase [NADP(+)]

Protein Summary
Description
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351829
  • ENSP00000312606
  • ENSG00000117448
  • ENST00000372070
  • ENSP00000361140
  • ENST00000621846
  • ENSP00000480713

Symbol
  • ALDR1
  • ALR
  • ALR
  • ARM
  • DD3
  • ALDR1
  • HEL-S-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
0.96
virus perturbation
0.76
cellular component
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.12   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 520   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.12   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
tolrestat
chemical structure image
Active Ligands (1)
1 – 1 of 1
CHEMBL273910
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
56.2
pulse pressure measurement
1
1
1
48.8
reticulocyte measurement
1
1
1
37.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
56.2
pulse pressure measurement
1
48.8
reticulocyte measurement
1
37.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member A1
VGNC:11731
741418
Macaque
alcohol dehydrogenase [Source:RefSeq peptide;Acc:NP_001248287]
Mouse
MGI:1929955
58810
Rat
RGD:68346
78959
Dog
aldo-keto reductase family 1 member A1
VGNC:37768
610537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member A1
Macaque
alcohol dehydrogenase [Source:RefSeq peptide;Acc:NP_001248287]
Mouse
Rat
Dog
aldo-keto reductase family 1 member A1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Formation of xylulose-5-phosphate
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Biological oxidations
Formation of xylulose-5-phosphate
Glutathione conjugation
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (85)
1 – 10 of 85
IGHG2
Tdark
p_int: 0.916060373
p_ni: 0.083902256
p_wrong: 0.000037371
Data Source: BioPlex
MIOX
Tbio
Family: Enzyme
Novelty: 0.00962281
Score: 0.949
Data Source: STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.0059198
Score: 0.946
Data Source: STRINGDB
ALDH9A1
Tbio
Family: Enzyme
Novelty: 0.01688006
Score: 0.945
Data Source: STRINGDB
ALDH3B2
Tbio
Family: Enzyme
Novelty: 0.08791168
Score: 0.943
Data Source: STRINGDB
GK
Tbio
Family: Kinase
Novelty: 0.00617547
Score: 0.936
Data Source: STRINGDB
ALDH1B1
Tbio
Family: Enzyme
Novelty: 0.01755208
Score: 0.933
Data Source: STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
Score: 0.931
Data Source: STRINGDB
ALDH3B1
Tbio
Family: Enzyme
Novelty: 0.03330389
Score: 0.93
Data Source: STRINGDB
ALDH1A3
Tbio
Family: Enzyme
Novelty: 0.00691116
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  165.12

PubMed score by year
PubTator Score  1511.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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