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Tbio
NID1
Nidogen-1

Protein Summary
Description
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264187
  • ENSP00000264187
  • ENSG00000116962
  • ENST00000366595
  • ENSP00000355554

Symbol
  • NID
  • NID
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.88
gene perturbation
0.71
histone modification site profile
0.68
microRNA
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.76   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.76   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.898763377
p_ni:  0.101236623
Data Source:  BioPlex
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.89534709
p_ni:  0.10465291
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.877008347
p_ni:  0.122991653
Data Source:  BioPlex
FBLN2
Tbio
Novelty:  0.01340024
p_int:  0.856173827
p_ni:  0.143826172
Score:  0.63
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.85530414
p_ni:  0.14469586
Data Source:  BioPlex
PSG1
Tbio
Novelty:  0.0239046
p_int:  0.825046072
p_ni:  0.174953928
Score:  0.2
Data Source:  BioPlex,STRINGDB
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.804360365
p_ni:  0.195639635
Score:  0.153
Data Source:  BioPlex,STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.996
Data Source:  Reactome,STRINGDB
LAMC1
Tbio
Novelty:  0.01230796
Score:  0.995
Data Source:  STRINGDB
LAMC3
Tbio
Novelty:  0.02221768
Score:  0.974
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Laminin interactions
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Laminin interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
3
3
95.5
neutrophil count
3
3
3
94.6
basophil percentage of leukocytes
2
2
2
88.3
monocyte count
2
2
2
88.2
myeloid white cell count
2
2
2
87.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
95.5
neutrophil count
3
94.6
basophil percentage of leukocytes
2
88.3
monocyte count
2
88.2
myeloid white cell count
2
87.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nidogen 1
VGNC:1414
469718
Macaque
nidogen 1
711154
Mouse
MGI:97342
18073
Rat
RGD:3178
25494
Dog
nidogen 1
VGNC:43807
488958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nidogen 1
Macaque
nidogen 1
Mouse
Rat
Dog
nidogen 1
Publication Statistics
PubMed Score 590.76
PubMed score by year
PubTator Score 134.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title