Protein Summary
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]
- ENST00000264187
- ENSP00000264187
- ENSG00000116962
- ENST00000366595
- ENSP00000355554
- NID
- NID
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
PubMedID | 0.88 | ||
gene perturbation | 0.71 | ||
histone modification site profile | 0.68 | ||
microRNA | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 590.76 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 382 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 590.76 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 382 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
ADAM18
Family: Enzyme
Novelty: 0.22622379
p_int: 0.898763377
p_ni: 0.101236623
Data Source: BioPlex
FBLN2
Novelty: 0.01340024
p_int: 0.856173827
p_ni: 0.143826172
Score: 0.63
Data Source: BioPlex,STRINGDB
PSG1
Novelty: 0.0239046
p_int: 0.825046072
p_ni: 0.174953928
Score: 0.2
Data Source: BioPlex,STRINGDB
TAZ
Novelty: 0.00372301
p_int: 0.804360365
p_ni: 0.195639635
Score: 0.153
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Laminin interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Laminin interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (6)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
basophil count | 3 | 3 | 3 | 95.5 | |||||
neutrophil count | 3 | 3 | 3 | 94.6 | |||||
basophil percentage of leukocytes | 2 | 2 | 2 | 88.3 | |||||
monocyte count | 2 | 2 | 2 | 88.2 | |||||
myeloid white cell count | 2 | 2 | 2 | 87.2 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
basophil count | 3 | 95.5 | |||||
neutrophil count | 3 | 94.6 | |||||
basophil percentage of leukocytes | 2 | 88.3 | |||||
monocyte count | 2 | 88.2 | |||||
myeloid white cell count | 2 | 87.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nidogen 1 | VGNC:1414 | 469718 | |||||
Macaque | nidogen 1 | 711154 | ||||||
Mouse | MGI:97342 | 18073 | ||||||
Rat | RGD:3178 | 25494 | ||||||
Dog | nidogen 1 | VGNC:43807 | 488958 | |||||
Publication Statistics
PubMed Score 590.76
PubMed score by year
PubTator Score 134.40
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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