Tbio NID1 Nidogen-1

Protein Summary

Description

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P14543
• Q14942
• Q59FL2
• Q5TAF2
• Q5TAF3
• Q86XD7
• NID-1

Gene Name

• NID1

Ensembl ID

• ENST00000264187
• ENSP00000264187
• ENSG00000116962
• ENST00000366595
• ENSP00000355554

Symbol

• NID
• NID

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.88
gene perturbation	0.71
histone modification site profile	0.68
microRNA	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.16   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 382   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.16   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0