Protein Summary
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
- ENST00000346454
- ENSP00000278597
- ENSG00000149295
- ENST00000362072
- ENSP00000354859
- ENST00000538967
- ENSP00000438215
- ENST00000542968
- ENSP00000442172
- D2R
- D2DR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
drug | 1 | ||
ligand (chemical) | 1 | ||
molecular function | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3685.77 (req: < 5)
Gene RIFs: 978 (req: <= 3)
Antibodies: 337 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3685.77 (req: >= 5)
Gene RIFs: 978 (req: > 3)
Antibodies: 337 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 103
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3210
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 81