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Tclin
ATP1B2
Sodium/potassium-transporting ATPase subunit beta-2

Protein Summary
Description
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth. The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the nu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250111
  • ENSP00000250111
  • ENSG00000129244

Symbol
  • AMOG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.79
gene perturbation
0.77
kinase perturbation
0.71
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.29   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.29   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
81.7
1
1
0
1.1
71.1
testosterone measurement
1
1
1
60.5
dihydrotestosterone measurement
1
1
1
60.5
mathematical ability
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
81.7
0
1.1
71.1
testosterone measurement
1
60.5
dihydrotestosterone measurement
1
60.5
mathematical ability
1
52
Pathways (28)
Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cardiac conduction
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Ion channel transport
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cardiac conduction
Cell surface interactions at the vascular wall
Hemostasis
Ion channel transport
Protein-Protein Interactions (102)
1 – 10 of 102
RTN4
Tbio
Novelty: 0.00080371
p_int: 0.999999181
p_ni: 8.19e-7
Score: 0.34
Data Source: BioPlex,STRINGDB
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.999866125
p_ni: 0.000010171
p_wrong: 0.000123704
Data Source: BioPlex
ATP1A1
Tclin
Family: Transporter
Novelty: 0.01078788
Score: 0.985
Data Source: Reactome,STRINGDB
ATP1A2
Tclin
Family: Transporter
Novelty: 0.00606202
Score: 0.982
Data Source: Reactome,STRINGDB
ATP1A3
Tclin
Family: Transporter
Novelty: 0.00485594
Score: 0.978
Data Source: Reactome,STRINGDB
ATP1A4
Tclin
Family: Transporter
Novelty: 0.01011201
Score: 0.973
Data Source: Reactome,STRINGDB
FXYD2
Tclin
Family: Enzyme
Novelty: 0.0196518
Score: 0.967
Data Source: STRINGDB
FXYD6
Tbio
Family: IC
Novelty: 0.0503209
Score: 0.931
Data Source: STRINGDB
FXYD3
Tbio
Family: IC
Novelty: 0.01217832
Score: 0.923
Data Source: STRINGDB
FXYD7
Tbio
Family: IC
Novelty: 0.08820333
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.29

PubMed score by year
PubTator Score  14.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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