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Tchem
SI
Sucrase-isomaltase, intestinal

Protein Summary
Description
Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides. This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264382
  • ENSP00000264382
  • ENSG00000090402
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.88
protein domain
0.73
cell line
0.64
cell type or tissue
0.51
chemical
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1821.29   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1821.29   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Approved Drugs (4)
1 – 4 of 4
acarbose
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miglustat
Rendered image for miglustat
miglitol
Rendered image for miglitol
migalastat
Rendered image for migalastat
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1,5 anhydroglucitol measurement
1
1
0
8.4
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1,5 anhydroglucitol measurement
0
8.4
17.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sucrase-isomaltase
VGNC:10046
470988
Mouse
MGI:1917233
69983
Rat
RGD:3675
497756
Dog
sucrase-isomaltase
VGNC:46161
488141
Horse
sucrase-isomaltase
VGNC:22970
100063242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sucrase-isomaltase
Mouse
Rat
Dog
sucrase-isomaltase
Horse
sucrase-isomaltase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14410-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary carbohydrate
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary carbohydrate
Disease
Diseases of carbohydrate metabolism
Protein-Protein Interactions (90)
1 – 10 of 90
AMY2A
Tclin
Family:  Enzyme
Novelty:  0.00132709
Score:  0.971
Data Source:  STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
Score:  0.964
Data Source:  STRINGDB
GLA
Tclin
Family:  Enzyme
Novelty:  0.00075604
Score:  0.963
Data Source:  STRINGDB
AMY2B
Tbio
Family:  Enzyme
Novelty:  0.01126737
Score:  0.957
Data Source:  STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.936
Data Source:  STRINGDB
GANC
Tchem
Family:  Enzyme
Novelty:  0.02123234
Score:  0.924
Data Source:  STRINGDB
GALM
Tbio
Family:  Enzyme
Novelty:  0.01067063
Score:  0.917
Data Source:  STRINGDB
KHK
Tchem
Family:  Kinase
Novelty:  0.00514172
Score:  0.91
Data Source:  STRINGDB
HKDC1
Tbio
Family:  Kinase
Novelty:  0.016969
Score:  0.909
Data Source:  STRINGDB
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
Score:  0.908
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1821.29

PubMed score by year
PubTator Score  1378.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer