Tbio COX7A2 Cytochrome c oxidase subunit 7A2, mitochondrial

Protein Summary

Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P14406
• B2R5E1
• Q3MIH5
• Q5TF59
• Q6FGI2

Gene Name

• COX7A2

Ensembl ID

• ENST00000230459
• ENSP00000230459
• ENSG00000112695

Symbol

• COX7AL
• VIIAL
• COX7AL
• COX7AL1
• COXVIIAL
• COXVIIa-L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.99
histone modification site profile	0.91
cellular component	0.74
transcription factor binding site profile	0.71

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 7a2, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 7a2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.12   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.12   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0