TRIM27
Zinc finger protein RFP
Protein Summary
E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It inter ...more
- ENST00000377194
- ENSP00000366399
- ENSG00000204713
- ENST00000377199
- ENSP00000366404
- ENST00000400720
- ENSP00000383555
- ENSG00000215641
- ENST00000412687
- ENSP00000416281
- ENSG00000234495
- ENST00000417660
- ENSP00000411026
- ENST00000427689
- ENSP00000388622
- ENSG00000237071
- ENST00000431123
- ENSP00000414793
- ENSG00000229006
- ENST00000435528
- ENSP00000405229
- ENST00000437160
- ENSP00000392787
- ENST00000452265
- ENSP00000412445
- RFP
- RNF76
- RFP
- RNF76
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
protein domain | 1 | ||
transcription factor perturbation | 1 | ||
disease perturbation | 0.96 | ||
kinase perturbation | 0.93 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.95 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.95 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.2 | 62.4 | ||||||
1 | 1 | 0 | 1.2 | 62.4 | ||||||
1 | 1 | 0 | 1.2 | 62.4 | ||||||
1 | 1 | 0 | 1.2 | 62.4 | ||||||
1 | 1 | 0 | 1.2 | 62.4 | ||||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 62.4 | |||||
0 | 1.2 | 62.4 | |||||
0 | 1.2 | 62.4 | |||||
0 | 1.2 | 62.4 | |||||
0 | 1.2 | 62.4 | |||||
Pathways (10)
Reactome (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Intracellular signaling by second messengers | ||||
Reactome | Metabolism of proteins | ||||
Reactome | PIP3 activates AKT signaling | ||||
Reactome | PTEN Regulation | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Intracellular signaling by second messengers | ||||
Metabolism of proteins | ||||
PIP3 activates AKT signaling | ||||
PTEN Regulation | ||||
Post-translational protein modification | ||||
Gene Ontology Terms (37)
Functions (8)
Components (10)
Processes (19)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (88)
1 – 10 of 88
DHX40
Family: Enzyme
Novelty: 0.27906444
p_int: 0.999370468
p_ni: 0.000629529
p_wrong: 3e-9
Data Source: BioPlex
ZNF219
Family: TF
Novelty: 0.17515242
p_int: 0.997142389
p_ni: 0.002857611
Score: 0.249
Data Source: BioPlex,STRINGDB
ZNF74
Family: TF
Novelty: 0.10554307
p_int: 0.993950856
p_ni: 0.006049065
p_wrong: 7.9e-8
Data Source: BioPlex
LGALS3BP
Novelty: 0.0025302
p_int: 0.988135268
p_ni: 0.011864732
Data Source: BioPlex
ZNF621
Family: TF
Novelty: 1.96460285
p_int: 0.983917512
p_ni: 0.016082488
Score: 0.218
Data Source: BioPlex,STRINGDB
EVA1B
Novelty: 2.1380272
p_int: 0.97564283
p_ni: 0.024357161
p_wrong: 9e-9
Data Source: BioPlex
NDEL1
Novelty: 0.01241819
p_int: 0.96998208
p_ni: 0.03001792
Data Source: BioPlex
MAP7
Novelty: 0.01976296
p_int: 0.949215446
p_ni: 0.050784285
p_wrong: 2.69e-7
Data Source: BioPlex
NDE1
Novelty: 0.00567438
p_int: 0.939853427
p_ni: 0.060146573
Score: 0.303
Data Source: BioPlex,STRINGDB
NOP53
Novelty: 0.00353077
p_int: 0.936152545
p_ni: 0.063847451
p_wrong: 4e-9
Data Source: BioPlex
Publication Statistics
PubMed Score 51.95
PubMed score by year
PubTator Score 402.78
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait