Tbio TRIM27 Zinc finger protein RFP

Protein Summary

Description

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P14373
• A2BE15
• Q5RJA8
• Q5ST26
• Q6LA73
• Q6NXR9
• Q9BZY6
• Q9UJL3

Gene Name

• TRIM27

Ensembl ID

• ENST00000377194
• ENSP00000366399
• ENSG00000204713
• ENST00000377199
• ENSP00000366404
• ENST00000400720
• ENSP00000383555
• ENSG00000215641
• ENST00000412687
• ENSP00000416281
• ENSG00000234495
• ENST00000417660
• ENSP00000411026
• ENST00000427689
• ENSP00000388622
• ENSG00000237071
• ENST00000431123
• ENSP00000414793
• ENSG00000229006
• ENST00000435528
• ENSP00000405229
• ENST00000437160
• ENSP00000392787
• ENST00000452265
• ENSP00000412445

Symbol

• RFP
• RNF76
• RFP
• RNF76

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
protein domain	1
transcription factor perturbation	1
disease perturbation	0.96
kinase perturbation	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.95   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.95   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0