Tbio TRIM27 Zinc finger protein RFP

Protein Summary

Description

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P14373
• A2BE15
• Q5RJA8
• Q5ST26
• Q6LA73
• Q6NXR9
• Q9BZY6
• Q9UJL3

Gene Name

• TRIM27

Ensembl ID

• ENST00000377194
• ENSP00000366399
• ENSG00000204713
• ENST00000377199
• ENSP00000366404
• ENST00000400720
• ENSP00000383555
• ENSG00000215641
• ENST00000412687
• ENSP00000416281
• ENSG00000234495
• ENST00000417660
• ENSP00000411026
• ENST00000427689
• ENSP00000388622
• ENSG00000237071
• ENST00000431123
• ENSP00000414793
• ENSG00000229006
• ENST00000435528
• ENSP00000405229
• ENST00000437160
• ENSP00000392787
• ENST00000452265
• ENSP00000412445

Symbol

• RFP
• RNF76
• RFP
• RNF76

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
protein domain	1
transcription factor perturbation	1
disease perturbation	0.96
kinase perturbation	0.93

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.95   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.95   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (14)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	ENSG00000215641	1	1	0	1.2	62.4
schizophrenia	EFO_0000692	ENSG00000234495	1	1	0	1.2	62.4
schizophrenia	EFO_0000692	ENSG00000229006	1	1	0	1.2	62.4
schizophrenia	EFO_0000692	ENSG00000237071	1	1	0	1.2	62.4
schizophrenia	EFO_0000692	ENSG00000204713	1	1	0	1.2	62.4

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	0	1.2	62.4
schizophrenia	EFO_0000692	0	1.2	62.4
schizophrenia	EFO_0000692	0	1.2	62.4
schizophrenia	EFO_0000692	0	1.2	62.4
schizophrenia	EFO_0000692	0	1.2	62.4

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Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tripartite motif containing 27	VGNC:12730	739369
Macaque	tripartite motif containing 27		706129
Mouse	tripartite motif-containing 27	MGI:97904	19720
Horse	tripartite motif containing 27	VGNC:24498	100060192
Cow	tripartite motif containing 27	VGNC:36323	520111

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tripartite motif containing 27
Macaque	tripartite motif containing 27
Mouse	tripartite motif-containing 27
Horse	tripartite motif containing 27
Cow	tripartite motif containing 27

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P14373-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)

Reactome (10)

Intracellular signaling by second messengers (R-HSA-9006925)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Intracellular signaling by second messengers	305 targets	R-HSA-9006925
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	PIP3 activates AKT signaling	266 targets	R-HSA-1257604
Reactome	PTEN Regulation	141 targets	R-HSA-6807070
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Intracellular signaling by second messengers	305 targets	R-HSA-9006925
Metabolism of proteins	2050 targets	R-HSA-392499
PIP3 activates AKT signaling	266 targets	R-HSA-1257604
PTEN Regulation	141 targets	R-HSA-6807070
Post-translational protein modification	1450 targets	R-HSA-597592

Gene Ontology Terms (37)

Functions (8)

Components (10)

Processes (19)

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1 – 8 of 8

GO Term	Evidence	Assigned by
SUMO transferase activity	Inferred from Experiment (EXP)	Reactome
ubiquitin protein ligase activity	Inferred from Experiment (EXP)	Reactome
ubiquitin-protein transferase activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
metal ion binding	Traceable Author Statement (TAS)	ProtInc
nucleic acid binding	Traceable Author Statement (TAS)	ProtInc
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (88)

Explore Interacting Targets

1 – 10 of 88

• See Interactions on String-DB

DHX40

Tdark

Family: Enzyme

Novelty: 0.27906444

p_int: 0.999370468

p_ni: 0.000629529

p_wrong: 3e-9

Data Source: BioPlex

ZNF219

Tbio

Family: TF

Novelty: 0.17515242

p_int: 0.997142389

p_ni: 0.002857611

Score: 0.249

Data Source: BioPlex,STRINGDB

ZNF74

Tbio

Family: TF

Novelty: 0.10554307

p_int: 0.993950856

p_ni: 0.006049065

p_wrong: 7.9e-8

Data Source: BioPlex

LGALS3BP

Tbio

Novelty: 0.0025302

p_int: 0.988135268

p_ni: 0.011864732

Data Source: BioPlex

ZNF621

Tdark

Family: TF

Novelty: 1.96460285

p_int: 0.983917512

p_ni: 0.016082488

Score: 0.218

Data Source: BioPlex,STRINGDB

EVA1B

Tdark

Novelty: 2.1380272

p_int: 0.97564283

p_ni: 0.024357161

p_wrong: 9e-9

Data Source: BioPlex

NDEL1

Tbio

Novelty: 0.01241819

p_int: 0.96998208

p_ni: 0.03001792

Data Source: BioPlex

MAP7

Tbio

Novelty: 0.01976296

p_int: 0.949215446

p_ni: 0.050784285

p_wrong: 2.69e-7

Data Source: BioPlex

NDE1

Tbio

Novelty: 0.00567438

p_int: 0.939853427

p_ni: 0.060146573

Score: 0.303

Data Source: BioPlex,STRINGDB

NOP53

Tbio

Novelty: 0.00353077

p_int: 0.936152545

p_ni: 0.063847451

p_wrong: 4e-9

Data Source: BioPlex

Publication Statistics

PubMed Score  51.95

PubMed score by year

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PubTator Score  402.78

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Chromosomal rearrangement
Coiled coil
Complete proteome
Cytoplasm
DNA-binding
Endosome
Metal-binding
Nucleus
Proto-oncogene

GWAS Trait Find Similar Targets

heel bone mineral density
HIV-1 infection
risk-taking behaviour
schizophrenia
self reported educational attainment
viral load

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging
neoplasm