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Tbio
TRIM27
Zinc finger protein RFP

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It inter ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377194
  • ENSP00000366399
  • ENSG00000204713
  • ENST00000377199
  • ENSP00000366404
  • ENST00000400720
  • ENSP00000383555
  • ENSG00000215641
  • ENST00000412687
  • ENSP00000416281
  • ENSG00000234495
  • ENST00000417660
  • ENSP00000411026
  • ENST00000427689
  • ENSP00000388622
  • ENSG00000237071
  • ENST00000431123
  • ENSP00000414793
  • ENSG00000229006
  • ENST00000435528
  • ENSP00000405229
  • ENST00000437160
  • ENSP00000392787
  • ENST00000452265
  • ENSP00000412445

Symbol
  • RFP
  • RNF76
  • RFP
  • RNF76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
transcription factor perturbation
1
disease perturbation
0.96
kinase perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.95   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.95   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
62.4
1
1
0
1.2
62.4
1
1
0
1.2
62.4
1
1
0
1.2
62.4
1
1
0
1.2
62.4
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
62.4
0
1.2
62.4
0
1.2
62.4
0
1.2
62.4
0
1.2
62.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 27
VGNC:12730
739369
Macaque
tripartite motif containing 27
706129
Mouse
MGI:97904
19720
Horse
tripartite motif containing 27
VGNC:24498
100060192
Cow
tripartite motif containing 27
VGNC:36323
520111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 27
Macaque
tripartite motif containing 27
Mouse
Horse
tripartite motif containing 27
Cow
tripartite motif containing 27
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P14373-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism of proteins
Reactome
PIP3 activates AKT signaling
Reactome
PTEN Regulation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
Metabolism of proteins
PIP3 activates AKT signaling
PTEN Regulation
Post-translational protein modification
Gene Ontology Terms (37)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (88)
1 – 10 of 88
DHX40
Tdark
Family: Enzyme
Novelty: 0.27906444
p_int: 0.999370468
p_ni: 0.000629529
p_wrong: 3e-9
Data Source: BioPlex
ZNF219
Tbio
Family: TF
Novelty: 0.17515242
p_int: 0.997142389
p_ni: 0.002857611
Score: 0.249
Data Source: BioPlex,STRINGDB
ZNF74
Tbio
Family: TF
Novelty: 0.10554307
p_int: 0.993950856
p_ni: 0.006049065
p_wrong: 7.9e-8
Data Source: BioPlex
LGALS3BP
Tbio
Novelty: 0.0025302
p_int: 0.988135268
p_ni: 0.011864732
Data Source: BioPlex
ZNF621
Tdark
Family: TF
Novelty: 1.96460285
p_int: 0.983917512
p_ni: 0.016082488
Score: 0.218
Data Source: BioPlex,STRINGDB
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.97564283
p_ni: 0.024357161
p_wrong: 9e-9
Data Source: BioPlex
NDEL1
Tbio
Novelty: 0.01241819
p_int: 0.96998208
p_ni: 0.03001792
Data Source: BioPlex
MAP7
Tbio
Novelty: 0.01976296
p_int: 0.949215446
p_ni: 0.050784285
p_wrong: 2.69e-7
Data Source: BioPlex
NDE1
Tbio
Novelty: 0.00567438
p_int: 0.939853427
p_ni: 0.060146573
Score: 0.303
Data Source: BioPlex,STRINGDB
NOP53
Tbio
Novelty: 0.00353077
p_int: 0.936152545
p_ni: 0.063847451
p_wrong: 4e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  51.95

PubMed score by year
PubTator Score  402.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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