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Tclin
FDPS
Farnesyl pyrophosphate synthase

Protein Summary
Description
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356657
  • ENSP00000349078
  • ENSG00000160752
  • ENST00000368356
  • ENSP00000357340
  • ENST00000447866
  • ENSP00000391755
  • ENST00000467076
  • ENSP00000480142
  • ENST00000612683
  • ENSP00000478235

Symbol
  • FPS
  • KIAA1293
  • FPS
  • FPPS
  • POROK9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
kinase perturbation
0.81
ligand (chemical)
0.8
transcription factor perturbation
0.74
small molecule perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 623.08   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 623.08   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 213
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (213)
isopentenyl diphosphate
Rendered image for isopentenyl diphosphate
cimadronate
Rendered image for cimadronate
Minodronate
Rendered image for Minodronate
NE21650
Rendered image for NE21650
BPH-252
Rendered image for BPH-252
BPH-715
Rendered image for BPH-715
CHEMBL4564934
Rendered image for CHEMBL4564934
Protein-Protein Interactions (141)
PDSS2
Tbio
Family:  Enzyme
Novelty:  0.02716477
p_int:  0.999953011
p_ni:  0.000046978
p_wrong:  1e-8
Score:  0.963
Data Source:  BioPlex,STRINGDB
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
p_int:  0.996506739
p_ni:  0.003493261
Score:  0.278
Data Source:  BioPlex,STRINGDB
CLPP
Tchem
Family:  Enzyme
Novelty:  0.00105289
p_int:  0.996503496
p_ni:  0.003496504
Score:  0.284
Data Source:  BioPlex,STRINGDB
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
p_int:  0.990153026
p_ni:  0.009846961
p_wrong:  1.3e-8
Score:  0.287
Data Source:  BioPlex,STRINGDB
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.977852079
p_ni:  0.022131894
p_wrong:  0.000016027
Score:  0.158
Data Source:  BioPlex,STRINGDB
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.959773473
p_ni:  0.040226524
p_wrong:  3e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
PDSS1
Tbio
Family:  Enzyme
Novelty:  0.01542427
p_int:  0.954849519
p_ni:  0.00040228
p_wrong:  0.0447482
Score:  0.977
Data Source:  BioPlex,STRINGDB
ALAS1
Tclin
Family:  Enzyme
Novelty:  0.00965779
p_int:  0.937024066
p_ni:  0.062099931
p_wrong:  0.000876003
Score:  0.183
Data Source:  BioPlex,STRINGDB
PSME4
Tbio
Novelty:  0.01206213
p_int:  0.899430943
p_ni:  0.100569057
Score:  0.177
Data Source:  BioPlex,STRINGDB
MMAB
Tbio
Family:  Enzyme
Novelty:  0.01681296
p_int:  0.891237456
p_ni:  0.108762539
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
4
93.8
2
2
0
1.3
90.8
reticulocyte count
6
2
10
89
red blood cell distribution width
2
2
2
85.2
hemoglobin measurement
1
2
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
4
93.8
0
1.3
90.8
reticulocyte count
10
89
red blood cell distribution width
2
85.2
hemoglobin measurement
2
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
farnesyl diphosphate synthase
VGNC:539
457366
Macaque
farnesyl diphosphate synthase
717761
Mouse
MGI:104888
110196
Rat
RGD:68953
83791
Dog
farnesyl diphosphate synthase
VGNC:40812
480129
Species
Name
OMA
EggNOG
Inparanoid
Chimp
farnesyl diphosphate synthase
Macaque
farnesyl diphosphate synthase
Mouse
Rat
Dog
farnesyl diphosphate synthase
Publication Statistics
PubMed Score 623.08
PubMed score by year
PubTator Score 351.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title