Tbio IRF2 Interferon regulatory factor 2

Protein Summary

Description

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P14316
• D6RCK5
• H0Y8S3
• Q6IAS7
• Q96B99
• IRF-2

Gene Name

• IRF2

Ensembl ID

• ENST00000393593
• ENSP00000377218
• ENSG00000168310

Symbol

• IRF-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.93
transcription factor binding site profile	0.93
histone modification site profile	0.77
virus perturbation	0.76
PubMedID	0.75

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Interferon Regulatory Factor 2

Protein / Nucleic Acid Binding / Interferon Regulatory Factor 2

Protein / ... / Winged Helix/forkhead Transcription Factor / Interferon Regulatory Factor 2

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Interferon Regulatory Factor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.43   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 467   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.43   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0