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Tbio
PRKCSH
Glucosidase 2 subunit beta

Protein Summary
Description
Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000587327
  • ENSP00000466012
  • ENSG00000130175
  • ENST00000589838
  • ENSP00000465461
  • ENST00000591462
  • ENSP00000465489

Symbol
  • G19P1
  • GIIB
  • PCLD
  • PLD1
  • G19P1
  • PCLD1
  • PKCSH
  • AGE-R2
  • VASAP-60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
co-expressed gene
0.96
transcription factor binding site profile
0.93
histone modification site profile
0.89
kinase perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.08   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.08   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
40.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
40.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C substrate 80K-H
455731
Mouse
MGI:107877
19089
Rat
RGD:1309628
300445
Dog
protein kinase C substrate 80K-H
VGNC:44984
484941
Horse
protein kinase C substrate 80K-H
VGNC:21849
100056942
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C substrate 80K-H
Mouse
Rat
Dog
protein kinase C substrate 80K-H
Horse
protein kinase C substrate 80K-H
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P14314-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Immune System
Innate Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (174)
1 – 10 of 174
FUK
Tbio
Family: Kinase
Novelty: 0.05169095
p_int: 0.995177697
p_ni: 0.000171275
p_wrong: 0.004651028
Score: 0.314
Data Source: BioPlex,STRINGDB
TSC2
Tbio
Novelty: 0.00067416
p_int: 0.990608065
p_ni: 0.009391648
p_wrong: 2.86e-7
Score: 0.266
Data Source: BioPlex,STRINGDB
DENND6A
Tbio
Novelty: 4.5572617
p_int: 0.9386309
p_ni: 0.061357996
p_wrong: 0.000011104
Score: 0.527
Data Source: BioPlex,STRINGDB
PEX14
Tbio
Novelty: 0.0210557
p_int: 0.917080681
p_ni: 0.082919319
Data Source: BioPlex
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.901554136
p_ni: 0.098445864
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.883279002
p_ni: 0.116720998
Data Source: BioPlex
EFNB3
Tbio
Novelty: 0.0120367
p_int: 0.866415381
p_ni: 0.133584619
Score: 0.552
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.853670355
p_ni: 0.146329645
Data Source: BioPlex
PITRM1
Tchem
Family: Enzyme
Novelty: 0.08067518
p_int: 0.831536232
p_ni: 0.168463768
Score: 0.234
Data Source: BioPlex,STRINGDB
SLC27A2
Tbio
Family: Transporter
Novelty: 0.01436035
p_int: 0.805997182
p_ni: 0.194002818
Data Source: BioPlex
Publication Statistics
PubMed Score  124.08

PubMed score by year
PubTator Score  44.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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