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Tchem
HGF
Hepatocyte growth factor

Protein Summary
Description
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222390
  • ENSP00000222390
  • ENSG00000019991
  • ENST00000423064
  • ENSP00000413829
  • ENST00000444829
  • ENSP00000389854
  • ENST00000453411
  • ENSP00000408270
  • ENST00000457544
  • ENSP00000391238
  • ENST00000644543
  • ENSP00000494899

Symbol
  • HPTA
  • SF
  • HGFB
  • HPTA
  • F-TCF
  • DFNB39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
protein domain
1
PubMedID
1
kinase perturbation
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3392.14   (req: < 5)
Gene RIFs: 635   (req: <= 3)
Antibodies: 919   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3392.14   (req: >= 5)
Gene RIFs: 635   (req: > 3)
Antibodies: 919   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
7
98.6
hepatocyte growth factor measurement
4
2
4
87.4
87.1
endothelial growth factor measurement
1
1
1
82.1
angiopoietin-2 receptor measurement
1
1
1
82.1
angiopoietin-2 measurement
1
1
1
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
7
98.6
hepatocyte growth factor measurement
4
87.4
87.1
endothelial growth factor measurement
1
82.1
angiopoietin-2 receptor measurement
1
82.1
angiopoietin-2 measurement
1
82.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hepatocyte growth factor
VGNC:7392
463503
Macaque
hepatocyte growth factor
708316
Mouse
MGI:96079
15234
Rat
RGD:2794
24446
Dog
hepatocyte growth factor
VGNC:41674
403441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hepatocyte growth factor
Macaque
hepatocyte growth factor
Mouse
Rat
Dog
hepatocyte growth factor
Protein Structure (28 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14210-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 28
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (108)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Gene Ontology Terms (50)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (458)
1 – 10 of 458
FKBP7
Tbio
Family: Enzyme
Novelty: 0.00572565
p_int: 0.764246759
p_ni: 0.235753241
Score: 0.538
Data Source: BioPlex,STRINGDB
MET
Tclin
Family: Kinase
Novelty: 0.00037995
Score: 0.999
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.992
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.984
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.984
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.98
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.979
Data Source: STRINGDB
IGF1
Tbio
Novelty: 0.00003878
Score: 0.978
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.977
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.977
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  3392.14

PubMed score by year
PubTator Score  2837.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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