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Tchem
MIF
Macrophage migration inhibitory factor

Protein Summary
Description
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215754
  • ENSP00000215754
  • ENSG00000240972
  • ENST00000613839
  • ENSP00000482779
  • ENSG00000276701

Symbol
  • GLIF
  • MMIF
  • GIF
  • GLIF
  • MMIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.96
hub protein
0.92
disease
0.9
gene perturbation
0.88


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1625.37   (req: < 5)
Gene RIFs: 556   (req: <= 3)
Antibodies: 675   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1625.37   (req: >= 5)
Gene RIFs: 556   (req: > 3)
Antibodies: 675   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Macrophage migration inhibitory factor [Source:UniProtKB/Swiss-Prot;Acc:Q6DN04]
Mouse
MGI:96982
17319
Rat
Horse
macrophage migration inhibitory factor
VGNC:50485
100053618
Cow
macrophage migration inhibitory factor
VGNC:49557
280858
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Macrophage migration inhibitory factor [Source:UniProtKB/Swiss-Prot;Acc:Q6DN04]
Mouse
Rat
Horse
macrophage migration inhibitory factor
Cow
macrophage migration inhibitory factor
Protein Structure (89 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14174-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 89
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Hemostasis
Immune System
Gene Ontology Terms (56)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (135)
1 – 10 of 135
PDHX
Tbio
Family: Enzyme
Novelty: 0.00946631
p_int: 0.987702793
p_ni: 0.012297207
Data Source: BioPlex
PDHA1
Tbio
Family: Enzyme
Novelty: 0.00392231
p_int: 0.952296575
p_ni: 0.047703425
Data Source: BioPlex
SEC22A
Tdark
Novelty: 0.44427127
p_int: 0.937908145
p_ni: 0.000141524
p_wrong: 0.061950331
Data Source: BioPlex
PDHB
Tbio
Family: Enzyme
Novelty: 0.01018086
p_int: 0.925840071
p_ni: 0.074159929
Data Source: BioPlex
PDK3
Tchem
Family: Kinase
Novelty: 0.05009442
p_int: 0.810957209
p_ni: 0.18904279
p_wrong: 1e-9
Data Source: BioPlex
WWP1
Tbio
Family: Enzyme
Novelty: 0.01407874
p_int: 0.803245275
p_ni: 0.196754725
Data Source: BioPlex
BCAT1
Tchem
Family: Enzyme
Novelty: 0.00616446
p_int: 0.78353173
p_ni: 0.216467881
p_wrong: 3.89e-7
Data Source: BioPlex
DLAT
Tbio
Family: Enzyme
Novelty: 0.00311191
p_int: 0.783185858
p_ni: 0.216814142
Data Source: BioPlex
CD74
Tchem
Novelty: 0.00281228
Score: 0.986
Data Source: Reactome,STRINGDB
GOT2
Tbio
Family: Enzyme
Novelty: 0.00054023
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  1625.37

PubMed score by year
PubTator Score  1687.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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