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Tbio
EDN3
Endothelin-3

Protein Summary
Description
Endothelins are endothelium-derived vasoconstrictor peptides. The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311585
  • ENSP00000311854
  • ENSG00000124205
  • ENST00000337938
  • ENSP00000337128
  • ENST00000371028
  • ENSP00000360067
  • ENST00000395654
  • ENSP00000379015

Symbol
  • ET3
  • ET-3
  • WS4B
  • HSCR4
  • PPET3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
trait
0.86
cell type or tissue
0.71
chemical
0.66
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748.77   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748.77   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (210)
1 – 10 of 210
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
Score:  0.995
Data Source:  Reactome,STRINGDB
EDNRA
Tclin
Family:  GPCR
Novelty:  0.00045591
Score:  0.99
Data Source:  Reactome,STRINGDB
KEL
Tbio
Family:  Enzyme
Novelty:  0.00264913
Score:  0.973
Data Source:  Reactome,STRINGDB
AVPR1A
Tclin
Family:  GPCR
Novelty:  0.00305957
Score:  0.959
Data Source:  STRINGDB
AGTR1
Tclin
Family:  GPCR
Novelty:  0.00033439
Score:  0.955
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.95
Data Source:  STRINGDB
ADRA1D
Tclin
Family:  GPCR
Novelty:  0.00203304
Score:  0.943
Data Source:  STRINGDB
ADRA1B
Tclin
Family:  GPCR
Novelty:  0.00381271
Score:  0.943
Data Source:  STRINGDB
AGTR2
Tchem
Family:  GPCR
Novelty:  0.00064774
Score:  0.94
Data Source:  STRINGDB
PROKR2
Tchem
Family:  GPCR
Novelty:  0.01400881
Score:  0.94
Data Source:  STRINGDB
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (34)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
73.9
lymphocyte percentage of leukocytes
1
1
1
72.6
lymphocyte count
1
1
1
68
hair color
2
2
0
1.1
59.6
2
1
0
1.1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
73.9
lymphocyte percentage of leukocytes
1
72.6
lymphocyte count
1
68
hair color
0
1.1
59.6
0
1.1
55.2
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelin 3
VGNC:6099
469989
Macaque
endothelin 3
693385
Mouse
MGI:95285
13616
Rat
RGD:2534
366270
Dog
endothelin 3
VGNC:40201
403406
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelin 3
Macaque
endothelin 3
Mouse
Rat
Dog
endothelin 3
Publication Statistics
PubMed Score 748.77
PubMed score by year
PubTator Score 349.94
PubTator score by year