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Tbio
GFAP
Glial fibrillary acidic protein

Protein Summary
Description
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435360
  • ENSP00000403962
  • ENSG00000131095
  • ENST00000588735
  • ENSP00000466598
  • ENST00000638281
  • ENSP00000491088

Symbol
  • ALXDRD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
gene perturbation
0.99
interacting protein
0.99
hub protein
0.98
kinase
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4425.61   (req: < 5)
Gene RIFs: 172   (req: <= 3)
Antibodies: 2703   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4425.61   (req: >= 5)
Gene RIFs: 172   (req: > 3)
Antibodies: 2703   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
9.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
9.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glial fibrillary acidic protein
VGNC:9296
454741
Macaque
glial fibrillary acidic protein
712941
Mouse
MGI:95697
14580
Rat
RGD:2679
24387
Dog
glial fibrillary acidic protein
VGNC:41180
480495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glial fibrillary acidic protein
Macaque
glial fibrillary acidic protein
Mouse
Rat
Dog
glial fibrillary acidic protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14136-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (58)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Chaperone Mediated Autophagy
Reactome
Nuclear signaling by ERBB4
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
Autophagy
Chaperone Mediated Autophagy
Nuclear signaling by ERBB4
Signal Transduction
Signaling by ERBB4
Protein-Protein Interactions (379)
1 – 10 of 379
DES
Tbio
Novelty: 0.00651741
p_int: 0.999999619
p_ni: 3.8e-7
p_wrong: 1e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
VIM
Tbio
Novelty: 0.00030317
p_int: 0.999935914
p_ni: 0.000064086
Score: 0.819
Data Source: BioPlex,Reactome,STRINGDB
P2RY8
Tbio
Family: GPCR
Novelty: 0.05574297
p_int: 0.999830539
p_ni: 0.000159158
p_wrong: 0.000010303
Data Source: BioPlex
INA
Tbio
Novelty: 0.00708581
p_int: 0.999717474
p_ni: 0.000282526
Score: 0.692
Data Source: BioPlex,STRINGDB
NES
Tbio
Novelty: 0.00035379
p_int: 0.999583129
p_ni: 0.000416871
Score: 0.805
Data Source: BioPlex,STRINGDB
ALG3
Tbio
Family: Enzyme
Novelty: 0.0159047
p_int: 0.999448137
p_ni: 0.000551863
Score: 0.209
Data Source: BioPlex,STRINGDB
NEFM
Tbio
Novelty: 0.00239134
p_int: 0.998050564
p_ni: 0.001949436
Score: 0.839
Data Source: BioPlex,STRINGDB
NT5DC1
Tdark
Family: Enzyme
Novelty: 0.33904133
p_int: 0.996732209
p_ni: 0.003267791
Score: 0.546
Data Source: BioPlex,STRINGDB
USP10
Tchem
Family: Enzyme
Novelty: 0.05830541
p_int: 0.995621763
p_ni: 0.004378191
p_wrong: 4.6e-8
Data Source: BioPlex
NHLH2
Tbio
Family: TF
Novelty: 0.04744703
p_int: 0.992110994
p_ni: 0.007884704
p_wrong: 0.000004302
Data Source: BioPlex
Publication Statistics
PubMed Score  4425.61

PubMed score by year
PubTator Score  2811.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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