HSD17B1
Estradiol 17-beta-dehydrogenase 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
phenotype | 0.85 | ||
protein domain | 0.73 | ||
biological term | 0.69 | ||
gene perturbation | 0.69 | ||
PubMedID | 0.68 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Estrogen biosynthesis | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Estrogen biosynthesis | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Metabolism | ||||
Metabolism of lipids | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Traceable Author Statement (TAS) | ProtInc | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
4 | 4 | 2 | 1 | 91.4 | |||||
waist-hip ratio | 3 | 6 | 6 | 82 | |||||
BMI-adjusted waist-hip ratio | 1 | 4 | 4 | 76.4 | |||||
sex hormone-binding globulin measurement | 4 | 2 | 4 | 75.4 | |||||
triglyceride measurement | 3 | 2 | 3 | 68.3 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
2 | 1 | 91.4 | |||||
waist-hip ratio | 6 | 82 | |||||
BMI-adjusted waist-hip ratio | 4 | 76.4 | |||||
sex hormone-binding globulin measurement | 4 | 75.4 | |||||
triglyceride measurement | 3 | 68.3 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | hydroxysteroid 17-beta dehydrogenase 1 | 454689 | ||||||
Macaque | hydroxysteroid 17-beta dehydrogenase 1 | 710392 | ||||||
Mouse | MGI:105077 | 15485 | ||||||
Rat | RGD:2836 | 25322 | ||||||
Dog | hydroxysteroid 17-beta dehydrogenase 1 | VGNC:41800 | 607570 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | hydroxysteroid 17-beta dehydrogenase 1 | |||||
Macaque | hydroxysteroid 17-beta dehydrogenase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hydroxysteroid 17-beta dehydrogenase 1 | |||||
PMID | Year | Title |
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