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Tchem
HSD3B1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Protein Classes
Protein Summary
Description
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable). The protein e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369413
  • ENSP00000358421
  • ENSG00000203857
  • ENST00000528909
  • ENSP00000432268

Symbol
  • 3BH
  • HSDB3A
  • HSD3B
  • HSDB3
  • HSDB3A
  • SDR11E1
  • 3BETAHSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.85
phenotype
0.83
cellular component
0.82
chemical
0.67
gene perturbation
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.59   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 468.59   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
469446
Mouse
MGI:104645
15496
Dog
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
483146
Horse
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
100034078
Cow
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
281824
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Mouse
Dog
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Horse
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Cow
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P14060-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (81)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Glucocorticoid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Glucocorticoid biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (119)
1 – 10 of 119
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
p_int: 1
Score: 0.933
Data Source: BioPlex,STRINGDB
CYP11A1
Tclin
Family: Enzyme
Novelty: 0.00096368
Score: 0.993
Data Source: STRINGDB
CYP17A1
Tclin
Family: Enzyme
Novelty: 0.00065091
Score: 0.993
Data Source: STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
Score: 0.992
Data Source: STRINGDB
CYP19A1
Tclin
Family: Enzyme
Novelty: 0.0003187
Score: 0.986
Data Source: STRINGDB
HSD17B3
Tchem
Family: Enzyme
Novelty: 0.00666322
Score: 0.978
Data Source: STRINGDB
CYP11B1
Tclin
Family: Enzyme
Novelty: 0.00195229
Score: 0.974
Data Source: STRINGDB
CYP11B2
Tchem
Novelty: 0.00128614
Score: 0.972
Data Source: STRINGDB
CYP21A2
Tchem
Family: Enzyme
Novelty: 0.00110959
Score: 0.97
Data Source: STRINGDB
SRD5A1
Tclin
Family: Enzyme
Novelty: 0.00987219
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  468.59

PubMed score by year
PubTator Score  373.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer