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Tchem
MTHFD2
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Protein Classes
Protein Summary
Description
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394053
  • ENSP00000377617
  • ENSG00000065911

Symbol
  • NMDMC
  • NMDMC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.91
virus perturbation
0.88
transcription factor binding site profile
0.81
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.19   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.19   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL297258
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
459331
Mouse
MGI:1338850
17768
Rat
RGD:1311313
680308
Dog
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
483107
Horse
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
100053990
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Mouse
Rat
Dog
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Horse
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (115)
1 – 10 of 115
MTHFD2L
Tdark
Family: Enzyme
Novelty: 0.18530504
p_int: 0.999999709
p_ni: 6.8e-8
p_wrong: 2.23e-7
Score: 0.98
Data Source: BioPlex,STRINGDB
SRP9
Tbio
Novelty: 0.02243103
p_int: 0.992219216
p_ni: 0.007780784
Score: 0.768
Data Source: BioPlex,STRINGDB
ACADL
Tbio
Family: Enzyme
Novelty: 0.0298212
p_int: 0.990547684
p_ni: 0.009452316
Score: 0.357
Data Source: BioPlex,STRINGDB
TFCP2
Tbio
Family: TF
Novelty: 0.00687548
p_int: 0.973548898
p_ni: 0.026451101
Score: 0.723
Data Source: BioPlex,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
p_int: 0.940694367
p_ni: 0.059270893
p_wrong: 0.00003474
Score: 0.255
Data Source: BioPlex,STRINGDB
UBP1
Tbio
Family: TF
Novelty: 0.01140885
p_int: 0.916358851
p_ni: 0.005695935
p_wrong: 0.077945214
Score: 0.693
Data Source: BioPlex,STRINGDB
ACAA1
Tbio
Family: Enzyme
Novelty: 0.00710465
p_int: 0.892850993
p_ni: 0.107149007
Score: 0.505
Data Source: BioPlex,STRINGDB
C2orf73
Tdark
Novelty: 0.8689571
p_int: 0.866612985
p_ni: 0.133387015
Data Source: BioPlex
RAB2B
Tdark
Family: Enzyme
Novelty: 0.18567584
p_int: 0.807225119
p_ni: 0.192774881
Data Source: BioPlex
GART
Tclin
Novelty: 0.00524985
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.19

PubMed score by year
PubTator Score  26.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer